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| Huang Yun ,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:huangyun@ems.hrbmu.edu.cn |
| 个人简介
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| Dr. Huang interested in cytogenetics, cell proliferation and apoptosis in cancer cells for several years. The current research interest focuses on the relationship between regulation of cytoskeleton and formation and stability of double minutes, extrachromosomal genetic elements, in malignant tumor cells. The researches may provide insights into potential target genes of cell cytoskeleton pathway in formation and stability of double minutes.
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| Liu Fangli ,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:liufl@ems.hrbmu.edu.cn |
| 个人简介
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| More than 10 years ago, I devoted to the function study of RAB5A gene in metastasis in lung adenocarcinoma and the next few years an expression library was established by using high metastatic lung adenocarcinoma cell line Anip973 to screening more tumor associated genes . In recent years, the relationship of double minutes in the occurrence and development of tumor was conducted.
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| Zhang Xuelong ,
Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:zhangxuel@ems.hrbmu.edu.cn |
| 个人简介
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| One of our research interests is to preserve the genetic resource of northern Chinese populations and study their genetic diversity. We have collected matched case and control samples for several diseases that have been of long-standing interest to the Department. These include autoimmune diseases, T2D, schizophrenia and HIV infection. We carried out association studies on these samples and demonstrated their genetic susceptibilities for these common complex diseases. Natural selection in different environments has played a role in shaping human genetic patterns. We have followed up the most highly differentiated non-synonymous SNPs identified by the HapMap project using resequencing data and additional tests for natural selection, and demonstrated that highly differentiated SNPs are often good indicators for positive selection in the human genome.
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| Xu Lidan,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:xuld@ems.hrbmu.edu.cn |
| 个人简介
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| We aim to preserve the genetic resource of northern Chinese populations, and study their genetic diversity as well as the association of genetic variants with common diseases. We have focused on the association between the gene polymorphisms and psoriasis, Grave’s disease, lactase persistence and HIV-1 infection. We have collected matched case and control samples and carried out the association studies. It was demonstrated that some SNPs was important for genetic susceptibilities of these common complex diseases.
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| Sun Donglin ,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:sundl@ems.hrbmu.edu.cn |
| 个人简介
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| Our research interests focus on the structure and function of double minutes chromosomes (DMs) on solid tumors, especially ovarian cancer. In our research, ovarian cancer cell lines were applied in functional studies, together with analysis on the histological parameters of clinical cases to interpret the function of genes on DMs worked on the ovarian cancer and a novel method to prognosis, diagnosis and individual treatment of ovarian cancer.
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| Sun Haiming,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:sunhm@ems.hrbmu.edu.cn |
| 个人简介
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| I got the MD. Degree from Qingdao University and then received the PhD. degree from the Harbin Medical University. I had extensive experience in population genetics, association studies and cancer epidemiology. Now our research is focused on the clinical biomarkers of colorectal cancer. We want to find some new biomarkers from the amplified genes on the double minutes.
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| Wu Jie,
M.D., Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:wujie412@163.com |
| 个人简介
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| We are working on understanding the mechanism that protein post-translation modification regulates DMs formation. We are also interesting in the relationship of microRNA and DMs formation regulatory mechanisms. This work provides new insights for decrease DMs and cancer therapy.
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| Zhu Jing,
Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:zhuj@ems.hrbmu.edu.cn |
| 个人简介
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| We study the molecular structure of Double minutes (DMs)-the marker of extrachromosomal gene amplification in human cancers. We analyze the molecular mechanism of the generation of DMs by studying the structure features of DMs and the aberration of the chromosome. How the gene amplification events are initiated and how the DMs are formed are particularly interested by using the cytogenetical, molecular-genetical methods and bioinformatic analysis.
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| Jia Xueyuan,
Ph.D.
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| 职称:157 Baojian Rd, Nangang Dist, Harbin 150081,China |
| 学历:86-451-86674798 |
| 研究生导师: |
| 邮箱地址:jiaxy@ems.hrbmu.edu.cn |
| 个人简介
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| Our research interests focus on the molecular structure and generation models of double minutes (DMs) in human tumors. We applied array CGH, FISH, NimbleGen capture array and high-throughput sequencing to analyze DMs, constructed DMs structures, and completed the whole sequences of DMs genome. DMs are the hallmarks of extrachromosomal gene amplification related to tumorigenesis and tumor progression. Molecular structure research of DMs provides us not only the amplified oncogenes but also the underlying molecular mechanisms for DMs formation. Our study indicated that high-throughput sequencing would be a powerful tool for researching the structure of DMs in solid tumors.
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| 杨翌,
硕士研究生导师
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| 职称:副教授 |
| 学历:博士 |
| 研究生导师: |
| 邮箱地址:yangyi@hrbmu.edu.cn |
| 个人简介
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| 目前主要研究方向是应用基因编辑技术、诱导多潜能干细胞技术以及单细胞测序技术开展单基因遗传病的干细胞与基因治疗以及疾病动物模型的构建。多年来在基因编辑研究方面取得了多项突破性进展，建立了一系列在生物医药领域具有重要应用价值的动物疾病模型以及基因治疗工具和递送载体的开发和应用，成果包括首次鉴定猪ROSA26位点并建立ROSA26定点敲入Cre重组酶报告基因的大动物模型；建立完全分泌人胰岛素的基因编辑猪，为异种胰岛移植治疗糖尿病提供理想供体；首次建立地中海贫血家兔模型，为地贫临床前基因治疗提供大动物模型；开发Mito-TALEN治疗线粒体遗传疾病的新技术；建立iPSC水平高效无痕、无筛选标记的基因打靶技术体系，为单基因遗传病的干细胞治疗提供新方法；在人造血干细胞水平建立了高效精准的靶向基因编辑体系，开展针对常见β地贫突变位点的通用型原位基因修复方案。目前以第一作者或通讯作者在Cell Research、Protein Cell、eLife、JBC等杂志发表高水平SCI论文7篇，作为项目负责人获得国家自然科学基金青年基金、中国博士后科学基金、广东省、广州市等基金。
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哈尔滨医科大学遗传学研究室. 版权所有 | 哈尔滨市南岗区保健路157号 | 电话: 86-451-86674798 传真: 86-451-86677243 邮箱: hmugenetics@ems.hrbmu.edu.cn |
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