Zhang Chun-yu received her MD. and PhD. degrees from the Harbin Medical University and finished her Postdoc training in Sun Yat-sen University/Hong Kong University. She has strong expertise in population genetics, gene function, tumor microenvironment and cancer stem cell. As a genetics professor, she has been committed to the genomic changes of tumor cells, especially in the study of extrachromosomal genetic units-double minutes (DMs). Now we current research interest focuses on the formation mechanism of DMs induced by oncogene and the functions of the new genes carried by DMs that involve changes of DNA damage-repair system, the activation of oncogenes and the participation of various signaling pathways in tumor cells.