Our research interests focus on identifying and elucidating the molecular mechanisms which govern the regulation of the tumorigenesis, gene amplification, drug resistance and DNA damage signaling in human cancer by employing functional genetic approaches such as genome-wide shRNA mediated loss-of-function screens, quantitative proteomic profilings, as well as model organisms including mouse models for human cancer and Schizosaccharomyces pombe (fission yeast).