Education

2000-2007      M.D. and M.S. in Basic Medicine, Harbin Medical University, Harbin, China

2007-2010       Ph.D. in Medical Genetics, Harbin Medical University, Harbin, China

Positions and Employment

2008.5-2013.12       Post-Doctoral Associate, Dept. of Pediatrics, Baylor College of Medicine, Houston, USA

2013.12-2017.4       Instructor, Dept. of Surgery, Houston Methodist Research Institute, Houston, USA

2017.4-present         Professor, Department of Immunology, Nantong Medical School, Nantong University

2018.6-present         Director, Basic Medical Research Center, Nantong Medical School, Nantong University

Honors and Awards

2010               The First Prize of Science and Technology Award of Heilongjiang province

2010               Innovation of Science and Technology Star at Harbin Medical University

2010               Outstanding Ph.D. student of Heilongjiang Province

2013               Third Award of Oral Presentation at 2013 SCBA TX SYMPOSIUM

2015               Distinguished Professor of Jiangsu Province

2017               The First Prize of Medical Science and Technology Award of Heilongjiang province

2017               Corresponding Editors of Organ Transplant

2018               Youth Science and Technology Award in Nantong City

Grants (as Principal Investigator- PI):

(1) National Natural Science Foundation of China 30801350

Fan (PI) 01/01/2009 – 12/30/2011

(200,000RMB).                                

(2) The Heilongjiang Province Office of Science and Technology

Education research project 11531446

Fan (PI) 01/01/2008 – 12/30/2010

(10,000RMB)

(3) The Heilongjiang Province Office of Health research project 2007-526

Fan (PI) 01/01/2007 – 12/30/2008

(1, 000RMB).

(4) Distinguished Professor of Jiangsu Province

Fan (PI) 2017.10-2020.10 (1000,000RMB)    

(5) National Natural Science Foundation of China 81641164

Fan (PI) 01/01/2017 – 12/30/2017

(100,000RMB).        

(6) National Natural Science Foundation of China 31770935

Fan (PI) 01/01/2018 – 12/30/2021

(550,000RMB).                                

Publications

1. Renfang Mao, Yuanyuan Wu, Yue Ming, Yuanpei Xu , Shouye Wang, Xia Cheng, Xiaoying Wang, Yihui Fan *. Enhancer RNAs: a missing regulatory layer in gene transcription. Science China Life Science, 2018, Accepted, (IF = 3.085)

2. Li F, Xue ZY, Yuan Y, Huang SS, Fan YH, Zhu X, Wei L. Upregulation of CXCR4 through promoter demethylation contributes to inflammatory hyperalgesia in rats. CNS Neurosci Ther. 2018 (IF = 3.495)

3. Chen Z, Shao XY, Wang C, Hua MH, Wang CN, Wang X, Wang QJ, Yao JY, Fan YH*, Qin YW*. Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. J Mol Neurosci. 2018 Feb;64(2):321-330. (IF = 2.454)

4. Wu Y, Wei J, Ming Y, Chen Z, Yu J, Mao R, Chen H, Zhou G, Fan Y *. Orchestrating a biomarker panel with lncRNAs and mRNAs for predicting survival in pancreatic ductal adenocarcinoma. J Cell Biochem. 2018 Jun 20. (IF = 2.959)

5. Li Y, Fan Y, Pan H, Qian H, Qi X, Wu G, Zhang H, Xu M, Rao Z, Wang L, Ying H. Effects of functional β-glucan on proliferation, differentiation, metabolism and its anti-fibrosis properties in muscle cells. Int J Biol Macromol. 2018 Oct 1;117:287-293. (IF = 3.909)

6. Yang R, Wu Y, Ming Y, Xu Y, Wang S, Shen J, Wang C, Chen X, Wang Y, Mao R, Fan Y *. A super-enhancer maintains homeostatic expression of Regnase-1. Gene. 2018 Aug 30;669:35-41. (IF = 2.498)

7. Fan M, Fan Y, Huang W, Wang L, Li Y, Qian H, Zhang H, Qi X. Tentative characterization of precursor compounds and co-factors of pigment formation in production of 'wu mi' from Vaccinium bracteatum Thunb. Leaves. Food Chem. 2018 Oct 1;262:199-205. (IF = 4.946)

8. Xiao X #, Fan Yihui #, Li J, Zhang X, Lou X, Dou Y, Shi X, Lan P, Xiao Y, Minze L, Li XC. Guidance of super-enhancers in regulation of IL-9 induction and airway inflammation. Journal of Experimental Medicine 215(2): 559 – 574. (IF = 13.912).(2018)

9. Wu J, Zhang H, Shi X, Xiao X, Fan Yihui, Minze LJ, Wang J, Ghobrial RM, Xia J, Sciammas R, Li XC, Chen W. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity 47(6): 1114-1128. (2017) (IF = 24.082).

10. Peixiang Lan, Yihui Fan, Xiang Xiao, Howard Monsour, Xiaolong Zhang, Yongwon Choi, Xian Chang Li. NKT cell death by pyroptosis driven by OX40 induces liver injury. Journal of Clinical Investigation 127（6）: 2222-2234 (2017) (IF = 12.784).

11. Renfang Mao, Riyun Yang, Xia Chen, Edward W. Harhaj, Xiaoying Wang, Yihui Fan *. Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses. Cellular and Molecular Immunology, 14（5）：412-422（2017）(IF = 5.193).

12. Xiang Xiao #, Xiaomin Shi # , Yihui Fan #, Chenglin Wu, Xiaolong Zhang, Laurie Minze, Wentao Liu, Rafik Ghobrial, Peixiang Lan, Xianchang Li. OX40 inhibits Th17 cells through activation of repressive chromatin remodeling pathways. Immunity 44: 1271-1283 (2016) (IF = 24.082).

13. Chenling Wu, Yue Zhao, Xiang Xiao, Yihui Fan, Malgorzata Kloc, Wentao Liu, Mark Ghobrial, Peixiang Lan, Xiaoshun He, Xianchang Li. Graft-infiltrating macrophages adopt an M2 phenotype and are inhibited by purinergic receptor P2X7 antagonist in chronic rejection. American Journal of Transplantation 16(9):2563-2573 (2016) (IF = 5.683).

14. Xiang Xiao, Xiaomin Shi, Yihui Fan, Xiaolong Zhang, Minhao Wu, Peixiang Lan, Luarie Minze, Yangxin Fu, Rafik M Ghobrial, Wentao Liu, Xianchang Li. GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation. Nature Communication 14 (6): 8266 (2015) (IF = 11.329).

15. Y Shi, IT Ma, RH Patel, X Shang, Z Chen, Y Zhao, J Cheng, Yihui Fan, Y Rojas, E Barbieri, Z Chen, Y Yu, J Jin, ES Kim, JM Shohet, SA Vasudevan, and J Yang. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death and Disease 6, e1841，(2015) (IF = 5.177)。

16. Zhang H, Dou J, Yu Y, Zhao Y, Fan Yihui, Cheng J, Xu X, Liu W, Guan S, Chen Z, shi Y, Patel R, Vasudevan SA, Zage PE, Zhang H, Nuchtern JG, Kim ES, Fu S, Yang J. mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling. Apoptosis 20(1):50-62 (2015) (IF = 3.614).

17. Cheng J #, Fan Yihui #, Xu X, Zhang H, Dou J, Tang Y, Zhong X, Rojas Y, Yu Y, Zhao Y, Vasudevan SA, Zhang H, Nuchtern JG, Kim ES, Chen X, Lu F, Yang J. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Disease 5: e1079 (2014) (IF = 5.177).

18. Yihui Fan,  Renfang Mao, Yang Yu, Shangfeng Liu, Zhongcheng Shi, Jin Cheng, Huiyuan Zhang, Lei An, Yanling Zhao, Xin Xu, Zhenghu Chen, Mari Kogiso, Dekai Zhang, Hong Zhang, Pumin Zhang, Jae U. Jung, Xiaonan Li, Guotong Xu, Jianhua Yang. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. Journal of Experimental Medicine 211(2):313-328 (2014) (Highlighted by Nature Immunology) (IF = 13.912).

19. Yihui Fan #, Ningling Ge #, Xiaosong Wang #, Wenjing Sun #, Renfang Mao, Wen Bu, Chad J. Creighton, Pingju Zheng, Sanjeev Vasudevan, Lei An, Jinshu Yang, Yi-Jue Zhao, Xiao-Nan Li, Pulivarthi  H. Rao, Eastwood Leung,  Yong-Jie Lu, Joe W. Gray, Rachel Schiff, Susan G. Hilsenbeck, C. Kent Osborne, Jianhua Yang, Hong Zhang. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells.  Journal of Pathology 232(1):75-86 (2014) (IF = 7.33).

20. Yihui Fan, Jin Cheng, Sanjeev A. Vasudevan, Roma H. Patel, Yanling Zhao, Wei Jia, Jed G. Nuchtern , Eugene S. Kim, Jianhua Yang. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death and Disease 4:e867 (2013) (IF = 5.177).

21. Yihui Fan#, Jin Cheng#, Sanjeev A. Vasudevan#, Roma H. Patel, Li Liang, Xin Xu, Yanling Zhao, Wei Jia, Fengmin Lu, Hong Zhang, Jed G. Nuchtern , Eugene S. Kim, Jianhua Yang. TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy. Apoptosis 18: 1224-1234 (2013) (IF = 3.614).

22. Lei An, Wei Jia, Yang Yu, Ning Zou, Liang Li, Yanling Zhao, Yihui Fan, Cheng Jin, Zhongcheng Shi, Gufeng Xu, Grace Li, Jianghua Yang, Hong Zhang. Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling. Scientific Reports 3: 2344 (2013) (IF = 5.078).

23. Jing Zhu, Yang Yu, Xiangning Meng, Yihui Fan, Yu Zhang, Chunshui Zhou, Zhichao Yue, Yan Jin, Chunyu Zhang, Lisa Yu, Wei Ji, Xueyuan Jia, Rongwei Guan, Jie Wu, Jingcui Yu, Jing Bai, Xinyuan Guan, Mingrong Wang, Kiyoung Lee, Wenjing Sun, Songbin Fu. De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes. International Journal of Cancer 133:797-806 (2013) (IF = 5.007).

24. Andreas Ernst, George Avvakumov, Jiefei Tong, Yihui Fan, Yanling Zhao, Philipp Alberts, Avinash Persaud, John R. Walker, Ana-Mirela Neculai, Dante Neculai, Andrew Vorobyov, Pankaj Garg, Linda Beatty, Pak-Kei Chan, Yu-Chi Juang, Marie-Claude Landry, Christina Yeh, Elton Zeqiraj, Konstantina Karamboulas, Abdellah Allali Hassani, Masoud Vedadi, Mike Tyers, Jason Moffat, Frank Sicheri, Laurence Pelletier, Daniel Durocher, Brian Raught, Daniela Rotin, Jianhua Yang, Michael F. Moran, Sirano Dhe Paganon, Sachdev S Sidhu. A Strategy for Modulation of Enzymes in the Ubiquitin System. Science 339:590-595 (2013) (Faculty of 1000 citation: Recommended) (IF = 31.477).

25. Yihui Fan *, Renfang Mao, Jianhua Yang. NF-kB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein & Cell 4(3):176-185 (2013).  (Review) (IF = 2.851).

26. Li Liang #, Yihui Fan #, Jin Cheng, Da Cheng, Yanling Zhao, Baoshan Cao, Liwei Ma, Lei An, Wei Jia, Xu Su, Jianhua Yang, Hong Zhang. TAK1 ubiquitination regulates doxorubicin-induced NF-kB activation. Cellular Signalling 25(1):247-254 (2013) (IF = 4.471).

27. Yanling Zhao #, Li Liang #, Yihui Fan #, Surong Sun, Lei An, Zhongchen Shi, Jin Cheng, Wei Jia, Weijing Sun, Yuko Mori-Akiyama, Hong Zhang, Songbin Fu, Jianhua Yang. PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cellular Signalling 24(11):2197-2204 (2012) (IF = 4.304).

28. Yihui Fan, Yi Shi, Shangfeng Liu, Renfang Mao, Lei An, Yanling Zhao, Hong Zhang, Zhang FC, Xu GT, Jun Qin, Jianhua Yang. Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-kB activation via mediating TAK1 degradation. Cellular Signalling 24(7):1381-1389 (2012) (IF = 4.304).

29. Yan Jin, Zheng Liu, Wei Cao, Xinying Ma, Yihui Fan, Yang Yu, Jing Bai, Feng Chen, Jesusa Rosales, Ki-Young Lee, Songbin Fu, Novel Functional MAR Elements of Double Minute Chromosomes in Human Ovarian Cells Capable of Enhancing Gene Expression. PLoS One 7(2): e30419 (2012) (IF = 3.73).

30. Yihui Fan, Yang Yu, Renfang Mao, Xiaojie Tan, Gufeng Xu, Hong Zhang, Xiongbin Lu, Songbin Fu, Jianhua Yang. USP4 targets TAK1 to downregulate TNFa-induced NF-kB activation. Cell Death and Differentiation 18:1547-1560 (2011) (IF = 8.849).

31. Yihui Fan, Yang Yu, Renfang Mao, Hong Zhang, Jianhua Yang. TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-kB activation. Cellular Signalling  23 (4): 660-665 (2011) (IF = 4.058).

32. Yihui Fan, Renfang Mao, Jing Bai, Songbin Fu. Frequency of double minute chromosomes and combined cytogenetic abnormalities and their characteristics. Journal of Applied Genetics  52:53-59 (2011) (IF = 1.664).

33. Renfang Mao, Yihui Fan, Songbin Fu, Jianhua Yang. TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-kB and JNK/AP-1 activation. Cellular Signalling  23 (1): 222-227 (2011) (IF = 4.058).

34. Renfang Mao #, Yihui Fan #, Lulu Zuo, Dongfeng Geng, Fantao Meng, Jing Zhu, Qiang Li, Hong Qian, Yan Jin, Jing Bai, Songbin Fu. Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves’ disease. Cell Biochemistry and Function 28: 585-590 (2010) (IF = 1.651).

35. Wenjing Sun, Hao Wang, Xuemei Zhao, Yan Yu, Yihui Fan, Hao Wang, Xishan Wang, Xiongbin Lu, Guiyin Zhang, Songbin Fu, Jianhua Yang. PP2A acts as a MEKK3 phosphatase to inhibit LPA induced IKK/NF-kB activation. The Journal of Biological Chemistry 285(28): 21341-21348 (2010) (IF = 5.328).

36. Yihui Fan, Yang Yu, Yi Shi, Wenjing Sun, Min Xie, Ningling Ge, Renfang Mao, Songbin Fu, Jun Qin, Jianhua Yang. Lys63-linked polyubiquitination of TAK1 at lysine 158 is required for TNF and IL-1-induced IKK/NF-B and JNK/AP1 activation. The Journal of Biological Chemistry 285(8): 5347-60 (2010) (Faculty of 1000 citation: Recommended) (IF = 5.328).

37. Wenjing Sun, Xiaojie Tan, Yi Shi, Gufeng Xu, Renfang Mao, Xue Gu, Yihui Fan, Yang Yu, Songbin Fu, Jianhua Yang. USP11negatively regulates TNFa-induced NF-kB activation by targeting on IkB. Cellular Signalling 22(3): 386-394, (2010) (IF = 4.243).

38. Yihui Fan, Renfang Mao, Songbin Fu, Jianhua Yang. TNF-α induces RelA degradation via ubiquitination at lys-195 to prevent excessive NF-kB activation. The Journal of Biological Chemistry 284(43): 29290-7 (2009) (IF = 5.328).

39. Wenjing Sun, Hongxiu Li, Yang Yu, Yihui Fan, Brian C. Grabiner, Renfang Mao, Hong Zhang, Songbin Fu, Jianhua Yang. MEKK3 is required for LPA-induced NF-kB activation. Cellular Signalling 21(10): 1488-1494, (2009) (IF = 4.094).

40. Renfang Mao, Yihui Fan, Yan Jin, Jing Bai, Songbin Fu. Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis. Journal of Human Genetics 53(4): 340-348, (2008) (IF = 2.526).

41. Renfang Mao, Yihui Fan, Songbin Fu.Genetic polymorphism of MTHFR G1793A in Chinese populations. European Journal of Epidemiology 23(5): 363-368, (2008) (IF = 2.572).

42. Renfang Mao, Yihui Fan, Feng Chen, Donglin Sun, Jing Bai, Songbin Fu. Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese populations. Cell Biochemistry and Function 26(3): 352-358, (2008) (IF = 1.333).

43. Yihui Fan #, Renfang Mao #, Jing Bai #, Xiaohong Zhang, Qingquan Lei, Songbin Fu. AFM images of G1-phase premature condensed chromosomes: evidence for 30nm changed to 50nm chromatin fibers. Applied Surface Science 254: 1676-1683, (2008) (IF = 1.576).

44. Yihui Fan #, Xiaohong Zhang #, Jing Bai #, Renfang Mao, Chunyu Zhang, Qingquan Lei, Songbin Fu. Ultrastructural organization of premature condensed chromosomes at S-phase as observed by atomic force microscopy. Applied Surface Science 253(12): 5281-5286, (2007) (IF = 1.406).