研究内容

 1. 肿瘤发生和转移的分子机制研究；

 2. 肿瘤进化的调控机制研究；

 3. 肿瘤干预策略的研究。

 发表学术文章

1. Yanting Jiang, Yue Sun, Jiandong Hu, Nan Yu, Hui Liu, Jiankun Fan, Xuelian Ning, Yilan Li, Baogang Liu,Yihua Sun, Jinwei Zhang, Xiaohong Qiu, Songbin Fu, Chunshui Zhou*, Hui Xu*. A Germline Mutation in Rab43 Gene Identified From a Cancer Family Predisposes to a Hereditary Liver-Colon Cancer Syndrome. BMC Cancer 2019 Jun,19(1):613.

2. Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H, Liang P*.Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma. Cell Death Dis. 2019,Sep 26;10(10):717.

3. Ji G, Liang H, Wang F, Wang N, Fu S, Cui X*. TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer. Mol Cells. 2019,Jul ,2(7):557-567.

4. Sun Y, Ning X, Fan J, Hu J, Jiang Y, Hu Z, Paulo JA, Liu J, Qiu X, Xu H, Fu S, Gygi SP, Zhang J, Zhou C. Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50. Cell Death Dis. 2020 Apr 27;11(4):292.

5. Zhu J, Huang J, Zhang P, Li Q, Kohli M, Huang CC, Wang L. Advantages of Single-Stranded DNA Over Double-Stranded DNA Library Preparation for Capturing Cell-Free Tumor DNA in Plasma. Mol Diagn Ther. 2020 Feb;24(1):95-101.

6. Raziq K, Cai M, Dong K, Wang P, Afrifa J, Fu S.Competitive endogenous network of lncRNA, miRNA, and mRNA in the chemoresistance of gastrointestinal tract adenocarcinomas. Biomed Pharmacother. 2020 Aug 4;130:110570.

7. Xu Z, Ji G, Cui Y, Cui X. The Impacts of Non-coding RNAs and N6-Methyladenosine on Cancer: Past, Present and Future. Curr Cancer Drug Targets. 2021;21(5):375-385.

8. Liu S, Gu L, Wu N, Song J, Yan J, Yang S, Feng Y, Wang Z, Wang L, Zhang Y*, Jin Y*. Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis. Cell Death Dis. 2021 Oct 11;12(10):929.

9. Chenyunping, Jin Yan*, Wu Nan*. Role of Tumor-Derived Extracellular Vesicles in Glioblastoma. Cells, 2021, 10(3): 512-526.

10. Wang, L., Lu, J., Song, Y., Bai, J., Sun, W., Yu, J., Cai, M., & Fu, S. (2022). Analysis of DNA Repair-Related Prognostic Function and Mechanism in Gastric Cancer.Frontiers in cell and developmental biology,10, 897096.

11. Wang, L., Song, Y., Bai, J., Sun, W., Yu, J., Cai, M., & Fu, S. (2022). Differential Infiltration of Immune Cells Driven by Tumor Heterogeneity Reveals Two Immune Subtypes in Lung Adenocarcinoma. Frontiers in genetics,13, 924781.

12. Wang, L., Cai, M., Song, Y., Bai, J., Sun, W., Yu, J., Du, S., Lu, J., & Fu, S. (2022). Multidimensional difference analysis in gastric cancer patients between high and low latitude. Frontiers in genetics,13, 944492.

13. Jiang, S., Zhang, Q., Li, J., Raziq, K., Kang, X., Liang, S., Sun, C., Liang, X., Zhao, D., Fu, S., & Cai, M. (2022). New Sights Into Long Non-Coding RNA LINC01133 in Cancer. Frontiers in oncology,12, 908162.

14. Zhang D, Zhou Y, Ma Y, Jiang P, Lv H, Liu S, Mu Y, Zhou C, Xiao S, Ji G, Liu P, Zhang N, Sun D, Sun H, Wu N, Jin Y. Ribosomal protein L22-like1 (RPL22L1) mediates sorafenib sensitivity via ERK in hepatocellular carcinoma. Cell Death Discovery. 2022,8:365.

15. Mo H, Wang X, Ji G, Liang X, Yang Y, Sun W, Jia X, Xu L, Qiao Y, Zhou H, Zhao W, Fu S, Zhang X. The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma. BMC Genomics. 2022 Nov 24;23(1):769.

16. Zhao, T., Yang, T., Zhang, J., Hao, H., Wang, D., Afirifa, J., Cai, M., Cui, X., Bai, J., Fu, S., & Yu, J. (2022). The promoter methylation drives down-regulation mode of HIC1 in gastric cancer, its molecular characteristics and downstream functional pathways. Gene,824, 146380.

17. Hu Z, Zhang M, Fan J, Hu J, Lin G, Piao S, Liu P, Liu J, Fu S, Sun W, Gygi SP, Zhang J, Zhou C. High-Level Secretion of Pregnancy Zone Protein Is a Novel Biomarker of DNA Damage-Induced Senescence and Promotes Spontaneous Senescence. J Proteome Res. 2023 Nov 3;22(11):3570-3579. doi: 10.1021/acs.jproteome.3c00403. Epub 2023 Oct 13. PMID: 37831546.

18. Du S, Qu H, Zhang Y, Zhu S, Wang Y, Zhang S, Wang Z, Yang Q, Fu S, Dong K. MiR-375 promotes cisplatin sensitivity of lung adenocarcinoma. Pathol Res Pract. 2023 Sep;249:154765. doi: 10.1016/j.prp.2023.154765. Epub 2023 Aug 14. PMID: 37625279.

19. Zhang Y#, Dong K#, Jia X#, Du S, Wang D, Wang L, Qu H, Zhu S, Wang Y, Wang Z, Zhang S, Sun W, Fu S. A novel extrachromosomal circular DNA related genes signature for overall survival prediction in patients with ovarian cancer. BMC Med Genomics. 2023 Jun 19;16(1):140.

20. Ying Zhang; Wenjing Sun; Jing Bai; Songbin Fu; Kexian Dong; Advances in long non-coding RNA regulating drug resistance of cancer. Gene. 2023, 887: 147726.

21. Zhou J, Bian H, Wu N*. Protein inhibitor of activated STAT3 (PIAS3) attenuates psoriasis and associated inflammation. Journal of Dermatology. 2023 Oct;50(10):1262-1271. doi: 10.1111/1346-8138.16874. Epub 2023 Jul 1. PMID: 37392066. 2023.07.11

22. Chen Y, Mu Y, Guan Q, Li C, Zhang Y, Xu Y, Zhou C, Guo Y, Ma Y, Zhao M, Ji G, Liu P, Sun D, Sun H, Wu N, Jin Y. RPL22L1, a novel candidate oncogene promotes temozolomide resistance by activating STAT3 in glioblastoma. Cell Death Dis. 2023 Nov 20;14(11):757.

23. Lv H, Mu Y, Zhang C, Zhao M, Jiang P, Xiao S, Sun H, Wu N, Sun D*, Jin Y*. Comparative analysis of single-cell transcriptome reveals heterogeneity and commonality in the immune microenvironment of colorectal cancer and inflammatory bowel disease. Frontiers in Immunology. 2024 Mar 11;15:1356075.

24. Hu Z, Lin G, Zhang M, Piao S, Fan J, Liu J, Liu P, Fu S, Sun W, Li L, Qiu X, Zhang J, Yang Y, Zhou C. Mechanistic Characterization of De Novo Generation of Variable Number Tandem Repeats in Circular Plasmids during Site-Directed Mutagenesis and Optimization for Coding Gene Application. Adv Biol (Weinh). 2024 Jun 16:e2400084.

25. 韩玥，孟祥宁，傅松滨. DNA双链断裂的非同源末端连接修复及临床应用. 国际遗传学杂志. 2019,42(2):124-129.

26. 魏筠妮, 张春玉, 傅松滨*. 分泌蛋白AGR2在肿瘤中的研究进展.国际遗传学杂志,2019,42( 2 ): 130-135.

27. 张赫, 张春玉, 傅松滨*. 外泌体蛋白质在恶性肿瘤中的作用.国际遗传学杂志,2019,42( 4 ): 272-278.

28. 余明辰，吴楠，孙冬琳，金焰*. 胶质母细胞瘤分子标志物的研究进展.癌变畸变突变. 2019,31(5):412-416.

29. 林楚雯，张春玉*. 肿瘤微环境中细胞融合机制的研究进展.国际遗传学杂志.2020（43）1:40-45.

30. 于森，孟祥宁，傅松滨*.表观遗传修饰与肿瘤细胞基因组不稳定性的关系. 国际遗传学杂志.2020（43）1:13-20

31. 朱刚，董科显，张春玉，傅松滨.结直肠癌恶型相关转录因子的研究进展. 国际遗传学杂志.2020（43）1:33-39.

32. 张涵威，孟祥宁.肿瘤缺氧微环境对DNA损伤应答过程的影响. 国际遗传学杂志.2020（43）2:99-105.

33. 姜胜男，董科显，蔡梦迪，傅松滨.肿瘤相关成纤维细胞中非编码RNA与肿瘤进展及临床应用研究进展.国际遗传学杂志.2020（43）5:264-270.

34. 秦倩，孙文靖.不断改进的CRISPR/Cas9基因编辑系统. 国际遗传学杂志.2020（43）5：257-263.

35. 刘雨蒙, 孙路遥, 张春玉*. 肿瘤相关成纤维细胞调控肿瘤免疫反应的研究进展[J]. 国际遗传学杂志,2021, 44(6):407-413.

36. 马亚南, 吴楠, 金焰*. 肿瘤微环境与卵巢癌化疗耐药机制的研究进展[J]. 癌变·畸变·突变, 2021, 33(5): 393-395, 400.

37. 雷常贵, 贾学渊, 孙文靖*. 基于癌症基因组图谱计划多组学数据构建胶质母细胞瘤六基因预后模型[J]. 遗传. 2021;43(7):665-679.

38. 屈函, 董科显, 傅松滨*. 组蛋白甲基转移酶和组蛋白去甲基化酶在卵巢癌中作用研究进展[J]. 中华实用诊断与治疗杂志. 2021;35(08)：854-856.

39. 付岩松,郭志涛,陈晨,孟祥宁,朱静*. miR-338-5P在人类恶性肿瘤等疾病中的作用和应用[J].生命科学,2021,33(08):1018-1027.

40. 柏小青, 孟祥宁. 肿瘤细胞中m6A功能的研究[J]. 国际遗传学杂志, 2021, 44(3) : 162-167.

41. 孟庆欣, 张慧姝, 朱静, 孟祥宁*. DNMT1与DNA损伤应答反应[J]. 国际遗传学杂志, 2021, 44(2) : 96-101.

42. 吴爽, 崔晓波*. 原发性肝癌发生发展的分子机制及药物治疗进展[J]. 国际遗传学杂志,2021, 44(6):431-438.

43. 王雨思, 张祎, 计薇, 吴杰. SUMO化修饰对维持基因组稳定性的作用[J]. 国际遗传学杂志,2021,44(1):60-66.

44. 史莉, 计薇. CRC中EMT的作用及靶向治疗研究进展. 生命科学, 2023; 35(4):463-471.

45. 刘子昂, 金焰, 吴楠. 真核生物mRNA 应激状态下的帽-非依赖性翻译. 中国生物化学与分子生物学报. 2023.DOI: 10.13865/j.cnki.cjbmb.2023.09.1192.

46. 王浩, 金焰, 吴楠. 肿瘤血管生成研究方法进展. 肿瘤防治研究. 2023;50(7):721-725.