中国遗传资源保护与疾病防控教育部重点实验室 English
   

中国人类遗传资源库-哈尔滨库的建立与应用研究

研究内容

1. 在收集大量北方人群疾病样本的基础上，建立人类恶性肿瘤组织样品库及中国东北地区常见复杂疾病和遗传病样本库；

2. 北方民族起源与民族之间亲缘关系研究；

3. 与疾病相关的基因多态性在中国北方人群中的分布研究；

4. 东北地区常见复杂疾病遗传学关联研究。


发表学术文章

  1. Wu J, Xu L, Liu B, Sun W, Hu Y, Yang Y, Guo K, Jia X, Sun H, Wu J, Huang Y, Ji W, Fu S, Qiao Y, Zhang X. Biomedical association analysis between G2/M checkpoint genes and susceptibility to HIV-1 infection and AIDS progression from a northern Chinese MSM population. AIDS Research and Therapy. 2023 Jul 19;20(1):51.

  2. .Zhang C, Zhong X, Yi L, Zhao Z, Zhang Y, Tan G, Zhang Y, Zhang Y*, Xu Y*, Wu N*. Exploring the Associations between Alzheimer's Disease and GBM Mediated by Microglia Based on Network Analysis. J Prev Alzheimers Dis. 2023;10(2):267-275. doi: 10.14283/jpad.2023.23. PMID: 36946454. 2023.03.17

  3. Zhang X, Wang X, Mo H, Hu Y, Yang Y, Yang X, Wu J, Liu B, Xu L, Sun H, Jia X, Wang P, Wang K, Sun W, Fu S, Qiao Y. Association of polymorphisms in NHEJ pathway genes with HIV-1 infection and AIDS progression in a northern Chinese MSM population. Dis Markers.2022 Oct 7.

  4. Zhang T, Li Q, Dong B, Liang X, Jia M, Bai J, Yu J, Fu S. Genetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China. Pharmgenomics Pers Med. 2021 Nov 30;14:1537-1547.

  5. Dong B, Li Q, Zhang T, Liang X, Jia M, Fu Y, Bai J, Fu S. Population Genetic Polymorphism of Skeletal Muscle Strength Related Genes in Five Ethnic Minorities in North China. Front Genet. 2021 Oct 11;12:756802.

  6. Wang H, Jiang Y, Yu L, Xu L, Guan R, Cai M, Dong K, Liang X, Bai J, Yu J*. The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China. BMC Gastroenterol. 2021 Sep 27;21(1):354.

  7. Qiuyan Li, Lidan Xu, Xueyuan Jia, Komal Saleem, Tahir Zaib, Wenjing Sun and Songbin Fu. SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis. Biosci Rep. 2020 Mar 27;40(3) ):BSR20194261.

  8. Guo X, Li C, Wu J, Mei Q, Liu C, Sun W, Xu L*, Fu S*.The association of TNF-α-308G/A and -238G/A polymorphisms with type 2 diabetes mellitus: a meta-analysis. Biosci Rep. 2019,Dec,39(12),BSR2019301.

  9. Zhang X, Qiao H, Zhao Y, Wang X, Sun H, Liu A, Xu L, Sun D, Jin Y, Yu Y, Meng X, Bai J, Chen F, Fu S*. (2012) Association of single nucleotide polymorphisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population.PLoS One. 7(12): e52938. PMID: 3534126

  10. Zhou J, Sun D, Xu L, Sun L, Fu S, Li Y*. (2011) ADAM33 as a psoriasis susceptibility gene in the Han population of northeastern China. Dermatology. 223(4):356-62. PMID: 22269827

  11. Qiao H, Zhang X, Zhao X, Zhao Y, Xu L, Sun H, Fu S*. (2012) Genetic variants of TCF7L2 are associated with type 2 diabetes in a northeastern Chinese population. Gene. 495(2):115-9. PMID: 22245614

  12. Han D, Shen C, Meng X, Bai J, Chen F, Yu Y, Jin Y, Fu S*. (2012) Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies. Mol Biol Rep. 39(2):805-16. PMID: 21547363

  13. Sun H, Bai J, Chen F, Jin Y, Yu Y, Fu S*. (2011) Lack of an association between AURKA T91A polymorphisms and breast cancer: a meta-analysis involving 32,141 subjects. Breast Cancer Res Treat. 125(1):175-9. PMID: 20464476

  14. Sun H, Bai J, Chen F, Jin Y, Yu Y, Jin L, Fu S*. (2011) RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects. Breast Cancer Res Treat. 125(1):157-61. PMID: 20454923

  15. Shen C, Sun H, Sun D, Xu L, Zhang X, Liu A, Jia X, Bai J, Chen F, Yu Y, Jin Y, Yu J, Fu S*. (2011) Polymorphisms of tumor necrosis factor-alpha and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 126(3):763-70. PMID: 20882404

  16. Sun H, Qiao Y, Zhang X, Xu L, Jia X, Sun D, Shen C, Liu A, Zhao Y, Jin Y, Yu Y, Bai J, Fu S*. (2010) XRCC3 Thr241Met polymorphism with lung caner and bladder cancer: A meta-analysis. Cancer Sci. 101(8):1777-82. PMID: 20500515

  17. Xu L, Yuan W, Sun H, Zhang X, Jia X, Shen C, Zhao Y, Sun D, Yu Y, Jin Y, Fu S*. (2011) The polymorphisms of the TNF-α gene in multiple sclerosis?-a meta-analysis. Mol Biol Rep. 38(6):4137-44. PMID: 21136171

  18. Wu J, Ren X, Zhang X, Li C, Li Y, Ma H, Zhou Y, Jin Y, Chen F, Bai J, Fu S*. (2010) The vascular endothelial growth factor +405 G/C polymorphism in psoriasis. J Dermatol Sci. 57(1):62-3. PMID: 19931423

  19. Xu L, Qiao Y, Zhang X, Sun H, Wang J, Sun D, Jia X, Shen C, Zhao Y, Jin Y, Yu Y, Ling H, Wang K, Fu S*. (2011) A haplotype in the CCR5 gene promoter was associated with the susceptibility to HIV-1 infection in a northern Chinese population. Mol Biol Rep. 38(1):327-32. PMID: 20364409

  20. Xu Z, Sun H, Yu Y, Jin Y, Meng X, Sun D, Bai J, Chen F, Fu S*. (2010) Diversity of five novel Y-STR loci and their application in studies of north Chinese populations. J Genet. 89(1):29-36. PMID: 20505244

  21. Jiang J, Zhang X, Sun D, Jin Y, Bai J, Chen F, Fu S*. (2010) Study on VNTR polymorphism of gene IL-1RA in 19 Chinese populations. Int J Immunogenet. 37(2):73-7. PMID: 20002810

  22. Xu L, Qiao Y, Zhang X, Sun H, Wang J, Sun D, Jin Y, Yu Y, Chen F, Bai J, Ling H, Wang K, Fu S*. (2010) CCR2-64I allele is associated with the progression of AIDS in a Han Chinese population. Mol Biol Rep. 37(1):311-6. PMID: 19669591

  23. Xu L, Sun H, Zhang X, Wang J, Sun D, Chen F, Bai J, Fu S*. (2010) The -22018A allele matches the lactase persistence phenotype in northern Chinese populations. Scand J Gastroenterol. 45(2):168-74. PMID: 19947896

  24. Xue Y, Zhang X, Huang N, Daly A, Gillson CJ, Macarthur DG, Yngvadottir B, Nica AC, Woodwark C, Chen Y, Conrad DF, Ayub Q, Mehdi SQ, Li P, Tyler-Smith C*. (2009) Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation. Genetics. 183(3):1065-77. PMID: 19737746

  25. Zheng L, Sun H, Wang J, Li S, Bai J, Jin Y, Yu Y, Chen F, Jin L, Fu S*. (2009) Y Chromosomal STR Polymorphism in Northern Chinese Populations. Biological Research. 42(4):497-504. PMID: 20140305

  26. Wang C, Chen F, Zhang X, Jin Y, Bai J, Fu S*. (2009) Polymorphic study of XRCC1 G28152A and XRCC1 C26304T in 10 Chinese populations. Biochem Genet. 47(1-2):27-32. PMID: 19067157

  27. Wu J, Chen F, Zhang X, Li Y, Ma H, Zhou Y, Jin Y, Wang H, Bai J, Zhang G, Fu S*. (2009) Association of MIF promoter polymorphisms with psoriasis in a Han population in northeastern China. J Dermatol Sci. 53(3):212-5. PMID: 19157791

  28. Wu J, Fu S, Ren X, Jin Y, Huang X, Zhang X, Bai J, Fu S*. (2009) Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. Tissue Antigens. 73(4):302-6. PMID: 19317738

  29. Mao R, Fan Y, Chen F, Sun D, Bai J, Fu S*. (2008) Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese ethnic populations. Cell Biochem Funct. 26(3):352-8. PMID: 18098118

  30. Mao R, Fan Y, Chen F, Fu S*. (2008) Genetic polymorphism of MTHFR G1793A in Chinese populations. Eur J Epidemiol. 23(5):363-8. PMID: 18409008

  31. Xue Y, Sun D, Daly A, Yang F, Zhou X, Zhao M, Huang N, Zerjal T, Lee C, Carter NP, Hurles ME, Tyler-Smith C*. (2008) Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet. 83(3):337-46. PMID: 18760392

  32. Zhang Z, Chen F, Zhang X, Jin Y, Bai J, Fu S*. (2008) PTPN22 allele polymorphisms in 15 Chinese populations. Int J Immunogenet. 35(6):433-7. PMID: 19046301

  33. Sun H, Qiao Y, Chen F, Xu L, Bai J, Fu S*. (2007) The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China. Asia Pac J Clin Nutr. 16(4):598-601. PMID: 18042517

  34. Zhang Y, Xue Y, Huang X, Ma L, Yu Y, Huang C, Zhang G, Li P, Fu S*. (2007) Genetic diversity of Y-chromosome microsatellites in the Fujian Han and the Sichuan Han populations of China. Anthropol Anz. 65(1):1-14. PMID: 17444187

  35. Xue Y, Zerjal T, Bao W, Zhu S, Shu Q, Xu J, Du R, Fu S, Li P, Hurles ME, Yang H, Tyler-Smith C*. (2006) Male Demography in East Asia: A North-South Contrast in Human Population Expansion Times. Genetics. 172(4):2431-9. PMID: 16489223

  36. Zhang X, Zhang C, Yu Y, Chen F, Li P, Fu S*. (2006) CCR2 allele polymorphisms in 15 Chinese ethnic populations. Int J Immunogenet. 33(1):45-8. PMID: 16426243

  37. Xue Y, Zerjal T, Bao W, Zhu S, Lim SK, Shu Q, Xu J, Du R, Fu S, Li P, Yang H, Tyler-Smith C*. (2005) Recent spread of a Y-chromosomal lineage in Northern China and Mongolia. Am J Hum Genet. 77(6):1112-6. PMID: 16380921

  38. Meng X, Xue Y, Sun D, Li P, Fu S*. (2005) Study on the Distribution of the MSY2 Polymorphism in 9 Chinese Populations. Anthropol Anz. 63(1):23-7. PMID: 15830585

  39. Ma L, Xue Y, Liu Y, Wang Z, Cui X, Li P, Fu S*. (2005) Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations. Hereditas. 142(2005):103-11. PMID: 16970620

  40. Huang X, Xue Y, Liu Y, Liu P, Zhang C, Li P, Fu S*. (2004) The distribution of six biallelic polymorphisms on non-recombining segments of the Y-chromosome in five Chinese populations. Anthropol Anz. 62(4):435-44. PMID: 15648852

  41. 张婷婷，董博南，李秋炎，傅松滨*. 中国不同人群常见药物代谢相关基因遗传多态性的研究进展[J]. 中华医学遗传学,2022,39(1):109-112.

  42. 杨祎, 孙文靖, 张学龙. m6A-SNPs及其在复杂疾病分子遗传学研究中的应用. 国际免疫学杂志, 2023; 46(2): 169-175.

 

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