My research is focused on DMs genes function and applyling in clinical diagnosis, therapy and pronogsis. DMs is a major phenotype of genome rearrangment during oncogenesis, whereas the function remain unkonwn. We had analysed the sequence of DMs genomes from two kinds of tumor cells, ovarian cancer and colorectal cancer, 27 tumor candidate genes accquired. We have two research projects, to evaluate whether these genes can be used as clinical biomarker and to investigate their precise regulation mechanisms in tumor cells.