中文版
 

Renfang Mao

Department of Pathophysiology, School of Medicine, Nantong University, 19 Qixiu Road, Nantong, Jiangsu

0513-85051678

maorenfang@ntu.edu.cn

 

 

Education

1999.9-2004.7        M.D., Clinical Medicine, Zhengzhou University

2005.9-2008.7        Master, Medical Genetics and Cell Biology, Harbin Medical University

2008.9-2011.7      Ph.D., Medical Genetics and Cell Biology, Harbin Medical University

Positions and Employment

2009.2-2010.10     PostDoc, Baylor College of Medicine, Department of Pathology & Immunology

2010.10-2013.10   PostDoc, Houston Methodist Research Institute, Department of Radiology

2014.9-2017.9       PostDoc, Houston Methodist Research Institute, Department of Cardiovascular Sciences

2017.9-present     Professor, Nantong Medical School, Nantong University, Department of Pathophysiology

Honors and Awards

2009               Excellent Thesis of Master Degree in Heilongjiang Province

2010               Excellent Thesis of Master Degree in Harbin Medical University

2011               Outstanding Ph.D. student of Heilongjiang Province

2017               Distinguished Professor of Jiangsu Province

Membership

American Heart Association, Student/Trainee Member (210178404), 2014-present

North American Vascular Biology Organization, Trainee Member (00022980), 2017-present

Grants (as Principal Investigator- PI):

 (1) Postdoctoral Fellowship of American Heart Association 17POST33410128

Mao (PI) 2017.1-2018.12 ($11,0300)

(2) National Natural Science Foundation of China 81600386

Mao (PI) 2017.1-2019.12 (175,000)                            

(3) National Natural Science Foundation of China 81873531

Mao (PI) 2019.1-2022.12 (570,000).                                

(4) Distinguished Professor of Jiangsu Province

Mao (PI) 2017.10-2020.10 (1000,000)     

 

Publications

1.       Renfang Mao, Yuanyuan Wu, Yue Ming, Yuanpei Xu , Shouye Wang, Xia Cheng, Xiaoying Wang, Yihui Fan. Enhancer RNAs: a missing regulatory layer in gene transcription. Science China Life Science, 2018, Accepted

2.       Yingcheng Wu, Jinhuan Wei, Yue Ming, Zhanghao Chen, Jinzhou Yu, Renfang Mao, Hao Chen, Guoxiong Zhou, Yihui Fan. Orchestrating a biomarker panel with lncRNAs and mRNAs for predicting survival in pancreatic ductal adenocarcinoma. Journal of Cellular Biochemistry doi: 10.1002/jcb.27119 (2018)

3.       Yangriyun, Yuanyuan Wu, Yue Ming, Yuanpei Xu, Shouye Wang, Jianbo Shen, Chenlu Wang, Xia Chen, Yongming Wang, Renfang Mao, Yihui Fan.  A super-enhancer maintains homeostatic expression of Regnase-1. Gene 30:35-41 (2018)

4.       Renfang Mao, Shu Meng, Qilin Gu, Raquel Araujo-Gutierrez, Sandeep Kumar, Qing Yan, Felicidad Almazan, Keith A Youker, Yingbin Fu, Henry J Pownall, John P Cooke, Yury I Miller, Yingbin Fu, Longhou Fang. AIBP limits angiogenesis through r-secretase-mediated upregulation of Notch Signaling. Circulation Research 120: 1727-1739 (2017) (IF = 11.551).

5.       Renfang Mao, Riyun Yang, Xia Chen, Edward W. Harhaj, Xiaoying Wang, Yihui Fan. Regnase-1, a rapid response ribonuclease regulating inflammation and conquering challenges. Cellular and Molecular Immunology. 14, 412-422 (2017) (IF = 5.193).

6.       Yihui Fan, Renfang Mao, Yang Yu, Shangfeng Liu, Zhongcheng Shi, Jin Cheng, Huiyuan Zhang, Lei An, Yanling Zhao, Xin Xu, Zhenghu Chen, Mari Kogiso, Dekai Zhang, Hong Zhang, Pumin Zhang, Jae U. Jung, Guotong Xu, Jianhua Yang. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. Journal of Experimental Medicine 211(2): 313-328 (2014) (IF = 12.810).

7.       Yihui Fan, Ningling Ge, Xiaosong Wang, Jie Dong, Wenjing Sun, Renfang Mao, Wen Bu, Chad J. Creighton, Pingju Zheng, Sanjeev Vasudevan, Lei An, Jinshu Yang, Yi-Jue Zhao, Xiao-Nan Li, Pulivarthi  H. Rao, Eastwood Leung,  Yong-Jie Lu, Joe W. Gray, Rachel Schiff, Susan G. Hilsenbeck, C. Kent Osborne, Yi Li, Jianhua Yang, Hong Zhang. MAP3K3 is amplified in human breast cancer and promotes formation and survival of breast cancer cells.  Journal of Pathology 232(1): 75-86 (2014) (IF = 7.33).

8.       Renfang Mao, Valentina Rubio, Huarong Chen, Li Bai, Oula C Mansour, Zheng-Zheng Shi. OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death and Disease 2013 Feb 14; 4:e491.

9.       Yihui Fan,  Renfang Mao, Yang Yu, Shangfeng Liu, Zhongcheng Shi, Jin Cheng, Huiyuan Zhang, Lei An,  Yanling Zhao, Xin Xu, Zhenghu Chen, Mari Kogiso, Dekai Zhang, Hong Zhang, Pumin Zhang, Jae U. Jung, Xiaonan Li, Guotong Xu, Jianhua Yang. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. Journal of Experimental Medicine 211(2):313-328 (2014).

10.    Yihui Fan, Ningling Ge, Xiaosong Wang, Jie Dong, Wenjing Sun, Renfang Mao, Wen Bu, Chad J. Creighton, Pingju Zheng, Sanjeev Vasudevan, Lei An, Jinshu Yang, Yi-Jue Zhao, Xiao-Nan Li, Pulivarthi  H. Rao, Eastwood Leung,  Yong-Jie Lu, Joe W. Gray, Rachel Schiff, Susan G. Hilsenbeck, C. Kent Osborne, Yi Li, Jianhua Yang, Hong Zhang. MAP3K3 is amplified in human breast cancer and promotes formation and survival of breast cancer cells. Journal of Pathology 232(1):75-86 (2014).

11.  Yihui Fan, Renfang Mao, Jianhua Yang. NF-kB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein & Cell 4(3):176-185 (2013).  (Review).

12.    Yihui Fan, Yi Shi, Shangfeng Liu, Renfang Mao, Lei An, Yanling Zhao, Hong Zhang, Zhang FC, Xu GT, Jun Qin, Jianhua Yang. Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation. Cell Signalling 24(7): 1381-1389, (2012)

13.    Yihui Fan, Yang Yu, Renfang Mao, Xiaojie Tan, Gufeng Xu, Hong Zhang, Xiongbin Lu, Jianhua Yang. USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation. Cell Death & Differentiation 18(10): 1547-1560, (2011)

14.    Yihui Fan, Yang Yu, Renfang Mao, Hong Zhang, Jianhua Yang. TAK1 Lys-158 but not lys-209 is required for IL-β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation. Cellular Signalling  23(4): 660-665, (2011)

15.    Yihui Fan, Renfang Mao, Hongpei, Lv, Jie Xue, Lei Yan, Yanhong Liu, Meng Shi, Guohua Ji, Jing Zhu, Yan Jin, Yang Yu, Jing Bai, Songbin Fu. Frequency of double minute chromosomes and combined cytogenetic abnormalities and their characteristics: a Mitelman Databe analysis. Jouranl of Applied Genetics 52(1): 53-59, (2011)

16.    Renfang Mao, Yihui Fan, Songbin Fu, Jianhua Yang. TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation. Cellular Signalling 23(1): 222-227, (2011)

17.    Renfang Mao, Yihui Fan, Songbin Fu. Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves’ disease. Cell Biochemistry and Function28(7): 585-590, (2010)

18.    Yihui Fan, Yang Yu, Yi Shi, Wenjing Sun, Min Xie, Ningling Ge, Renfang Mao, Alex Chang, Gufeng Xu, Schneider D. Schneider, Songbin Fu, Jun Qin, Jianhua Yang. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha and interleukin-1 beta-induced IKK/NF-κB and JNK/AP-1 activation. The Journal of Biological Chemistry 285(8): 5347-5360, (2010)

19.    Wenjing Sun, Xiaojie Tan, Yi Shi, Gufeng Xu, Renfang Mao, Xue Gu, Yihui Fan, Yang Yu, Susan Burlingame, Hong Zhang, Surya P. Rednam, Xiongbin Lu, Ting Zhang, Songbin Fu, Guangwen Cao, Jun Qin, Jianhua Yang. USP11negatively regulates TNFα-induced NF-κB activation by targenting on IκBα.Cell Signalling 22(3): 386-394, (2010).

20.    Yihui Fan, Renfang Mao, Yangling Zhao, Yang Yu, Wengjing Sun, Ping Song, Zhongcheng Shi, Dekai Zhang, Eric Yvon, Hong Zhang, Songbin Fu, Jianhua Yang. Tumor necrosis factor-α induces RelA degradation via ubiquitination at lys-195 to prevent excessive nuclear factor- κB activation. The Journal of Biological Chemistry 284(43): 29290-29297 (2009).

21.    Wenjing Sun, Hongxiu Li, Yang Yu, Yihui Fan, Brian C. Grabiner, Renfang Mao, Ningling Ge, Hong Zhang, Songbin Fu, Xin Lin, Jianhua Yang. MEKK3 is required for lysphosphatidic acid-induced NF-kB activation.) Cell Signalling21(10): 1488-1494, (2009).

22.    Renfang Mao, Yihui Fan, Yan Jin, Jing Bai, Songbin Fu. Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis. Journal of Human Genetics 53(4): 340-348, (2008).

23.    Renfang Mao, Yihui Fan, Feng Chen, Songbin Fu.Genetic polymorphism of MTHFR G1793A in Chinese populations. European Journal of Epidemiology 23(5): 363-368, (2008).

24.    Renfang Mao, Yihui Fan, Songbin Fu. Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese populations. Cell Biochemistry and Function 26(3): 352-358, (2008).

25.    Yihui Fan, Renfang Mao (Co-first author), Jing Bai, Xiaohong Zhang, Qingquan Lei, Songbin Fu. AFM images of G1-phase premature condensed chromosomes: evidence for 30nm changed to 50nm chromatin fibers. Applied Surface Science 254: 1676-1683, (2008).

26.    Yihui Fan, Xiaohong Zhang, Jing Bai, Renfang Mao, Chunyu Zhang, Qingquan Lei, Songbin Fu. Ultrastructural organization of premature condensed chromosomes at S-phase as observed by atomic force microscopy. Applied Surface Science 253(12): 5281-5286, (2007).

27.    Yihui Fan, Renfang Mao, Songbin Fu. A review of the research on double minute chromosomes. International Journal of Genetics 31(4): 248-266, (2008). (Review, Chinese)

28.    Renfang Mao, Yihui Fan, Jing Bai, Songbin Fu. Polymorphisms of methylenetetrahydrofolate reductase and association with disease. International Journal of Genetics 30(1): 39-44, (2007). (Review, Chinese)

29.    Renfang Mao, Yihui Fan, Songbin Fu. Milestones in Cancer. International Journal of Genetics 29 (6): 136-137, (2006). (Review, Chinese)

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