In 1962, a particular extrachromosomal small body structure was observed and reported in the pleural effusion of lung cancer. Afterwards, these structures were named double minute chromosomes (DMs). As an extrachromosomal gene amplification marker, DMs are acentric, atelomeric, and self-replicating bodies existing in pairs, which usually carry oncogenes and drug resistance genes and are closely...
Research summaryIn 1978, our laboratory launched the cytogenetic research in human solid tumors. From the initial cytogenetic analysis in solid tumors to the molecular-DNA level research in the 1990s, our laboratory has been dedicated in the gene structure and function research in human malignant tumors. In 2001, the study of “Cytogenetic Research in Solid Tumor” was awarded with the second p...
Research summaryChina has the biggest population of any country in the world, accounting for about 20% of the global population. More than 95% belong to the Han ethnic group, but there are also 55 minorities, providing a rich human resource for evolutionary and population genetic studies. One of our research interests is to preserve the genetic resource of these Chinese populations and study th...
Research summaryWith the development and improvement of human lifestyle, the spectrum of human disease has undergone the structural changes. The incidence of birth defects and inherited diseases increased year by year. At present, the incidence of birth defects in China is 4% to 6%, and about 800 thousand to 1 million defective children were born each year. The congenital heart disease, cleft l...
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