Job Title: Research Associate
Department/Institution/Faculty: Laboratory of Medical Genetics, Harbin Medical University, Faculty
Date Posted:  04/27/2018
Application Deadline: Open Until Filled
  
Job Description
The Harbin Medical University, Laboratory of Medical Genetics aims at combining classical cytogenetic, molecular biology and high throughput techniques as next-generation sequencing to understand Causes, mechanisms and early intervention of inherited diseases and birth defects in Chinese populations. In order to decipher the mechanisms in cancer genesis and chemo-resistance, another major project we focused on was the study on Structure study and function analysis of tumor related genes in human malignancies. We have collected blood and tissue samples of patients with common solid tumors in north China. So far, we have established a tumor genetic resource library of north China, including but not limited to stomach cancer, colorectal cancer, lung cancer and ovarian cancer. Detailed information can be found on http://genetics.hrbmu.edu.cn

Within the frame of these projects, our group is now inviting applications for two RESEARCH ASSOCIATE positions. Applicants should be highly motivated M.D. and/or Ph.D. who have a solid experience and publications path in the area of cancer genetics and computational genetics, especially in bioinformatics analysis of genomics and proteomics data. Candidates are expected to be highly passionate and motivated, flexible in their commitment, collaborative and have good written and oral communication skills in English. The successful candidate will enjoy working with passionate fellow researchers, in an intellectually stimulating environment, where open discussion, exchange of ideas and creativity are considered as the basis of scientific research. Our preferred application is by email with a curriculum vitae and a list of publications to:

Songbin Fu, M.D., Ph.D.
Professor
Vice President of Harbin Medical University
Laboratory of Medical Genetics
Harbin Medical University
157 Baojian Road, Nangang District
Harbin 150081, China
Email: fusb@ems.hrbmu.edu.cn

 

Job Title: Postdoctoral Research Associate
Division/ Department/Faculty: Laboratory of Medical Genetics, Harbin Medical University, Faculty
Date Posted:  04/27/2018
Application Deadline: Open Until Filled
  
Job Description

The Harbin Medical University, Laboratory of Medical Genetics aims at combining classical cytogenetic and high throughput techniques as next-generation sequencing to understand Causes, mechanisms and early intervention of inherited diseases and birth defects in Chinese populations. In order to decipher the mechanisms in cancer genesis and chemo-resistance, another major project we focused on was the study on Structure study and function analysis of tumor related genes in human malignancies. We have collected the blood and tissue samples of patients with common solid tumors including but not limited to stomach cancer, colorectal cancer, lung cancer and ovarian cancer in north China. Meanwhile, we are also interested in the Structure and Function of Double Minute Chromosomes (DMs), which deals with the mechanism of genome instability and chemo-resistance in cancer, and the Evolution of diverse Human Ethnics in China, with the purpose to uncover the mystery of how current people came from their ancients. Being nominated as the Harbin Bank, one of the major divisions of the Human Genome Project of China, our group has deposited blood samples of subpopulations of all 56 ethnic populations in China, as well as samples of disease and control of multiple genetic disorders. Detailed information can be found on http://genetics.hrbmu.edu.cn

Two Postdoctoral Associate positions are available immediately for motivated scientists with Ph.D. and/or M.D. degree and a strong background in cancer genetics and computational genetics, especially in bioinformatics analysis of genomics and proteomics data. Candidates are expected to be highly passionate and motivated, flexible in their commitment, collaborative and have good written and oral communication skills in English. The successful candidate will enjoy working with passionate fellow researchers, in an intellectually stimulating environment, where open discussion, exchange of ideas and creativity are considered as the basis of scientific research. Our preferred application is by email with a curriculum vitae and a list of publications to:

Songbin Fu, M.D., Ph.D.
Professor
Vice President of Harbin Medical University
Laboratory of Medical Genetics
Harbin Medical University
157 Baojian Road, Nangang District
Harbin 150081, China
Email: fusb@ems.hrbmu.edu.cn

These projects are supported by “National Natural Science Foundation of China” grants.

Publication:

1. Pang B, Wu N, Guan R, Pang L, Li X, Li S, Tang L, Guo Y, Chen J, Sun D, Sun H, Dai J, Bai J, Ji G, Liu P, Liu A, Wang Q, Xiao S, Fu S, Jin Y.Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial-Mesenchymal Transition. Clin Cancer Res. 2017, 15; 23(18):5598-5610.

2. Li Y, Sun H, Zhang C, Liu J, Zhang H, Fan F, Everley RA, Ning X, Sun Y, Hu J, Liu J, Zhang J, Ye W, Qiu X, Dai S, Liu B, Xu H, Fu S, Gygi SP, Zhou C. Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics. Oncogene. 2017 Dec 14; 36(50):6839-6849.

3. You J, Liu J, Bao Y, Wang L, Yu Y, Wang L, Wu D, Liu C, Wang N, Wang F, Wang F, Xu L, Tian X, Liang H, Gao Y, Guan R, Bai J, Meng X, Sun W, Guan XY, Zhang C, Fu S, Jin Y.SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer. Cancer Lett. 2017, 28; 385: 271-279.

4. Zhu J, Zhang F, Du M, Zhang P, Fu S, Wang L. Molecular characterization of cell-free eccDNAs in human plasma. Sci Rep. 2017,8;7(1):10968.

5. Wang Y, Wu N, Sun D, Sun H, Tong D, Liu D, Pang B, Li S, Wei J, Dai J, Liu Y, Bai J, Geng J, Fu S, Jin Y. NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition. Cancer Sci. 2017, 108(6):1169-1176.

6. Liu D, Wang Y, Dong M, Guan S, Wang Y, Sun H, Wu N, Li S, Bai J, Chen F, Sun D, Jin Y. Polymorphisms in cytokine genes as prognostic markers in diffuse large B cell lymphoma patients treated with (R)-CHOP. Ann Hematol. 2017, 96(2):227-235.

7. Li Q, Qiao Y, Zhang G, He N, Zhang X, Jia X, Sun H, Wang C, Xu L. Association of single nucleotide polymorphisms of APOBEC3G with susceptibility to HIV-1 infection and disease progression among men engaging in homosexual activity in northern China. Archives of Virology, 2017, 162(1):259-268

8. Jing Zhou, Yuzhen Li, Donglin Sun. Associations between STAT Gene Polymorphisms and Pso- riasis in Northeastern China. Dermatology,2017,233:30-36

9. Wu J, Song HF, Li SH, Guo J, Tsang K, Tumiati L, Butany J, Yau TM, Ouzounian M, Fu S, David TE, Weisel RD, Li RK. Progressive Aortic Dilation Is Regulated by miR-17-Associated miRNAs. J Am Coll Cardiol. 2016, 28; 67(25): 2965-77

10. Qiuyan Li, Yuandong Qiao, Chuntao Wang, Guangfa Zhang, Xuelong Zhang, Lidan Xu. Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis. Endocrine. 2016, 51(1):52-62

11. Hao Wang, Man Xu, Xiaobo Cui, Yixin Liu, Yi Zhang, Yu Sui, Dong Wang, Lei Peng, Dexu Wang, Jingcui Yu. Aberrant expression of the candidate tumor suppressor gene DAL-1 due to hypermethylation in gastric cancer. Scientific Reports. 2016, 6: 21755.

12. Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ. Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks. Proc Natl Acad Sci U S A. 2016, 113(26):E3667-75.

13. Meng X, Qi X, Guo H, Cai M, Li C, Zhu J, Chen F, Guo H, Li J, Zhao Y, Liu P, Jia X, Yu J, Zhang C, Sun W, Yu Y, Jin Y, Bai J, Wang M,Rosales J, Lee KY, Fu S*.Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells. J Med Genet. 2015, 52(2):135-44.    

14. Meng X, Wang G, Guan R, Jia X, Gao W, Wu J, Yu J, Liu P, Yu Y, Sun W, Dong H, Fu S*. Predicting chemosensitivity to gemcitabine and cisplatin based on gene polymorphisms and mRNA expression in non-small-cell lung cancer cells. Pharmacogenomics. 2015, 16 (1):23-34.

15. Sun W, Quan C, Huang Y, Ji W, Yu L, Li X, Zhang Y, Zheng Z, Zou H, Li Q, Xu P, Feng Y, Li L, Zhang Y, Cui Y, Jia X, Meng X, Zhang C, Jin Y, Bai J, Yu J, Yu Y,Yang J*, Fu S*. Constitutive ERK1/2 activation contributes to production of double minute chromosomes in tumour cells. J Pathol, 2015; 235(1):14-24.

16. Huiyuan Zhang, Jun Dou, Yang Yu, Yanling Zhao, Yihui Fan, Jin Cheng, Xin Xu, Wei Liu, Shan Guan, Zhenghu Chen, Yan shi, Roma Patel, Sanjeev A,  Vasudevan, Peter E. Zage, Hong Zhang, Jed G. Nuchtern, Eugene S. Kim, Songbin Fu*, Jianhua Yang*.mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling. Apoptosis. 20(1):50-62.

17. Xu H, Sun H, Zhang H, Liu J, Fan F, Li Y, Ning X, Sun Y, Dai S, Liu B, Gao2015, M, Fu S, Zhou C*.An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling. PLos One. 2015, 11; 10(5):e0124033

18. Xu H, Dephoure N, Sun H, Zhang H, Fan F, Liu J, Ning X, Dai S, Liu B, Gao M, Fu S, Gygi SP*, Zhou C*.Proteomic Profiling of Paclitaxel Treated Cells Identifies a Novel Mechanism of Drug Resistance Mediated by PDCD4. J Proteome Res.  2015, 5; 14(6):2480-91.

19. Xu J, Liu P, Meng X, Bai J, Fu S, Guan R*, Sun W*. Association between sister chromatid exchange and double minute chromosomes in human tumor cells. Mol Cytogenet. 2015, 19;8:91..

20. Nan Wu, Jia Wei, Yuhui Wang, Jinyan Yan, Ying Qin, Dandan Tong, Bo Pang, Donglin Sun, Haiming Sun, Yang Yu, Wenjing Sun, Xiangning Meng, Chunyu Zhang, Jing Bai, Feng Chen, Jingshu Geng, Ki-Young Lee, Songbin Fu*, Yan Jin*. Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition. Plos One. 2015, 10 (11).

21. Ji W, Bian Z, Yu Y, Yuan C, Liu Y, Yu L, Li C, Zhu J, Jia X, Guan R, Zhang C, Meng X, Jin Y, Bai J, Yu J, Lee KY, Sun W*, Fu S*.Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells. Int J Cancer. 2014, 134(6):1279-88.

22. Jie Wu，Sol Kim，Man Sup Kwak，Jang Bin Jeong，Hyun Jin Min，Ho-Geun Yoon，Jin-Hyun Ahn， Jeon-Soo Shin*.High Mobility Group Nucleosomal Binding Domain 2(HMGN2) SUMOylation by the SUMO E3 Ligase PIAS1Decreases the Binding Affinity to Nucleosome Core Particles.The Journal of Biological Chemistry. 2014, 289(29) 20000–20011.

23. Zhu J, Yu Y, Meng X, Fan Y, Zhang Y, Zhou C, Yue Z, Jin Y, Zhang C, Yu L, Ji W, Jia X, Guan R, Wu J, Yu J, Bai J, Guan XY, Wang M, Lee KY, Sun W, Fu S*. De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes. Int J Cancer. 2013, 133(4):797-806.

24. Fan Y, Yu Y, Mao R, Tan X, Xu G, Zhang H, Lu X, Fu S, Yang J*. USP4 targets TAK1 to downregulate TNFalpha-induced NF-kappaB activation. Cell Death Differ. 2011,18(10):1547-60.

25. Shi Z, Cai Z, Sanchez A, Zhang T, Wen S, Wang J, Yang J, Fu S*, Zhang D*. A novel Toll-like receptor that recognizes vesicular stomatitis virus. J Biol Chem. 2011,286(6):4517-24.

26. Sun W, Wang H, Zhao X, Yu Y, Fan Y, Wang X, Lu X, Zhang G, Fu S*, Yang J*. Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. J Biol Chem. 2010, 285(28):21341-8.

27. Sun W, Ge N, Yu Y, Burlingame S, Li X, Zhang M, Ye S, Fu S, Yang J*.Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. J Biol Chem. 2010, 285(11):7911-8.

28. Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J*.Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010, 285(8):5347-60.

29. Xu Z, Sun H, Yu Y, Jin Y, Meng X, Sun D, Bai J, Chen F, Fu S*. Diversity of five novel Y-STR loci and their application in studies of north Chinese populations. J Genet. 2010, 89(1):29-36.

30. Fan Y, Mao R, Zhao Y, Yu Y, Sun W, Song P, Shi Z, Zhang D, Yvon E, Zhang H, Fu S, Yang J*. Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. J Biol Chem. 2009, 284(43):29290-7.

31. Zhang C, Fu L, Fu J, Hu L, Yang H, Rong T, Li Y, Liu H, Fu S, Zeng Y, Guan X*.Fibroblast growth factor receptor 2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res. 2009, 15(12):4017-27.

32. Shi Z, Cai Z, Wen S, Chen C, Gendron C, Sanchez A, Patterson K, Fu S, Yang J, Wildman D, Finnell RH, Zhang D*. Transcriptional regulation of the novel Toll-like receptor Tlr13. J Biol Chem. 2009, 284(31):20540-7.

33. Li M, Jin Y, Sun W, Yu Y, Bai J, Tong D, Qi J, Du J, Geng J, Huang Q, Huang X, Huang Y, Han F, Meng X, Rosales JL, Lee KY, Fu S*. Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. J Pathol. 2009, 219(1):87-95.

34. Meng X, Jin Y, Yu Y, Bai J, Liu G, Zhu J, Zhao Y, Wang Z, Chen F, Lee KY, Fu S*. Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer. 2009, 101(2):327-34.

35. Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J*. Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem. 2008, 283(36):24497-505.

36. Xue Y, Sun D, Daly A, Yang F, Zhou X, Zhao M, Huang N, Zerjal T, Lee C, Carter NP, Hurles ME, Tyler-Smith C*. Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet. 2008, 83(3):337-46.

37. Xue Y, Zerjal T, Bao W, Zhu S, Shu Q, Xu J, Du R, Fu S, Li P, Hurles ME, Yang H, Tyler-Smith C*. Male demography in East Asia: a north-south contrast in human population expansion times. Genetics. 2006, 172(4):2431-9.

38. Gao L, Qin W, Cui H, Feng G, Liu P, Gao W, Ma L, Li P, He L, Fu S*.A novel locus of coralliform cataract mapped to chromosome 2p24-pter. J Hum Genet. 2005, 50(6):305-10.

39. Xue Y, Zerjal T, Bao W, Zhu S, Lim SK, Shu Q, Xu J, Du R, Fu S, Li P, Yang H, Tyler-Smith C*. Recent spread of a Y-chromosomal lineage in northern China and Mongolia. Am J Hum Genet. 2005, 77(6):1112-6.

40. Guan X*, Fu S, Xia J, Fang Y, Sham JS, Du B, Zhou H, Lu S, Wang B, Lin Y, Liang Q, Li X, Du B, Ning X, Du J, Li P, Trent JM. Recurrent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization. Cancer Genet Cytogenet. 2000, 123(1):27-34.

41. Xia J, Lu S, Geng J, Fu S, Li P, Liu Q. Direct chromosome analysis of ten primary gastric cancers. Cancer Genet Cytogenet. 1998, 102(1):88-90.

42. Fu S*, Li P. Cytogenetic study of twenty-three primary squamous cell carcinomas of the lung. Cancer Genet Cytogenet. 1997, 99(1):54-8.

43. Fu S*, Li P, Feng X, Liu C, Liu Q. The origin of isochromosomes and their significance in tumorigenesis of human lung cancer. Cancer Genet Cytogenet. 1994, 74(2):120-2.

44. Lu Y, Xiao S, Yan Y, Fu S, Liu Q, Li P*. Direct chromosome analysis of 50 primary breast carcinomas. Cancer Genet Cytogenet. 1993, 69(2):91-9.