Yan Chenghui-哈尔滨医科大学遗传学研究室

Yan Chenghui

Department of Cardiology

ShenyangNorthern hospital

Shenyang 110016

People’s Republic of China

PERSONAL INFORMATION

Sex	Female
Birth Place	Harbin, Hei Long-jiang province, China
Date of Birth	Oct. 29.1973
Citizenship	The People’s Republic of China
Health	Excellent

EDUCATIONexperiences

Jan.2014-present	Professor, key Cardiovascular Laboratory of PLA, shenyang northern hospital, liaoning, China
Jan.2007-Dec.2013	Associate professor, Laboratory of Cardiovascular department, shenyang northern hospital, liaoning, China
Aug.2003-Dec.2006	Doctor, Laboratory of Cardiovascular department, shenyang northern hospital, liaoning, China
Sep.2000-July.2003	PhD student of Medical Genetics Major in Department of Medical Genetics, Harbin Medical University, Helongjiang, China. Director: Pro. Fu song-bin
Sep.1997-July.2000	Master of Medical Genetics Major in Department of Medical Genetics, Harbin Medical University, Helongjiang, China. Director: Pro. Fu song-bin
Sep.1991-Jul.1996	Bachelor of medical examination, Dalian medical college, Dalian, Liaoning province, china

careerEXPERIENCES

Apr.2013-present	Vice director of key Cardiovascular Laboratory of PLA, Shenyang Northern hospital. liaoning, China Research area: The biological role and mechanism study of CREG1 gene against cardiovascular disease.
Aug.2003-Feb.2013	Doctor, Laboratory of Cardiovascular department, shenyang northern hospital, liaoning, China Research area: The biological role and mechanism study of CREG1 gene against cardiovascular disease.
Sep.2001-July. 2003	PH.D. Student, Lab of medical genetics, Harbin medical university, Helongjiang, china Research area: The study on molecular mechanism of Lung carcinoma metastasis
Sep.1998-July.2000	M.D. Student，Lab of medical genetics, Harbin medical university, Helongjiang, China Research area: Gene therapy in Lung cancer

RESEARCH AREA:

The biological role of CREG1 gene against vascular restenosis after PCI, atherosclerotic inflammation and provide novel strategies for the early prevention of these diseases; the role and molecular mechanisms of CREG1 during embryonic blood vessel formation; the regulation of CREG1 gene on iPS cell-based cardiogenesis and on iCM reprogramming, and use of CREG1 as a therapeutic agent to improve the transplanation of iCM or cardiomyocytes form iPS cells, etc.

ACADEMIC DUTY:

1. Member, the Basic Group, Cardiovascular Society, Chinese Medical Association

2. Member, standing of Young committee, Cardiovascular Society of PLA, Chinese Medical Association

PROJECTS:

1. CREG gene acts as an endogenous regulating factor to protect vascular endothelium from injury (2011.1-2013.12, NSFC, General program, No: 81070097, PI);

2. Role of CREG gene in regulating cardiogenesis in iPS cells and reprogram in iCM cells (2012.1-2016.12，NSFC, Key program，No: 81130072，key participant)

3. Effect of transplantation of CREG modified iPS cells in a mouse acute myocardial infarction model (2011.4-2013.8, Prophase National Basic Research Program No: 2011CB512111, key participant)

PUBLICATIONS:

1.Yan CH, Fang P, Tao J, Zhang HM, Tian XX, Li Y, Zhang J, Sun MY , Li SH, Wang H, Han YL. Cellular Repressor of E1A-stimulated Genes (CREG) Promotes Angiogenesis and Neovascularization, Front Biosci, accepted, 2014

2.Tian XX, Zhang N, Yan CH, Nelson J, Liu SW, Kang J, Zhang J, Peng CF, Tao J, Sun MY, Li Y, Li SH, Wang H, Han YL. CREG Promotes Vasculogenesis in Mouse Embryonic Stem Cells by Activation of VEGF/PI3K/Akt Pathway, Front Biosci, accepted, 2014

3. Zheng W, Yan C, Wang X, Luo Z, Chen F, Yang Y, Liu D, Gai X, Hou J, Huang M. TheTGFB1 functional polymorphism rs1800469 and susceptibility to atrial fibrillation in two Chinese Han populations. PLoS One. 2013; 8(12) :e83033.

4. Duan Y, Liu S, Tao J, You Y, Yang G, Yan C, Han Y. Cellular repressor of E1A stimulated genes enhances endothelial monolayer integrity. Mol Biol Rep, 2013, 40(6): 3891-3900

5.Deng J, Han Y, Sun M, Tao J, Yan C, Kang J, Li S. Nanoporous CREG-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries. PLoS One, 2013, 8(4): e60735

6. Wang J, Yan CH, Li Y, Xu K, Tian XX, Peng CF, Tao J, Sun MY, Han YL.

MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes. Exp Cell Res. 2013;319(8):1165-75.

7.Li Y, Tao J, Zhang J, Tian X, Liu S, Sun M, Zhang X, Yan C, Han Y. Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation. Atherosclerosis, 2012, 225(2): 304-314

8. Li Y, Yan CH, Li SH, Han YL. CREG: a possible candidate for both prevention and treatment of proliferative vascular disease. Curr Mol Med, 2012, 12(10): 1273-1281

9. Wang N, Han Y, Tao J, Huang M, You Y, Zhang H, Liu S, Zhang X, Yan C. Overexpression of CREG attenuates atherosclerotic endothelium apoptosisvia VEGF/PI3K/AKT pathway. Atherosclerosis,2011, 218(2): 543-551

10. Zhang H, Han Y, Tao J, Liu S, Yan C, Li S. Cellular repressor of E1A-stimulated genes regulates vascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathway. Exp Cell Res, 2011, 317(20): 2904-2913

11. Han Y, Luan B, Sun M, Guo L, Guo P, Tao J, Deng J, Wu G, Liu S, Yan C, Li S. Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells. J Mol Cell Cardiol. 2011;50(4):723-30.

12.Han Y, Wu G, Deng J, Tao J, Guo L, Tian X, Kang J, Zhang X, Yan C. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. J Mol Cell Cardiol. 2010;48(6):1225-35.

13.Deng J, Han Y, Yan C, Tian X, Tao J, Kang J, Li S. Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt. Apoptosis. 2010;15(4):463-73.

14.Huang M, Han Y, Zhang X, Pei F, Deng J, Kang J, Yan C. An intron polymorphism in the CXCL16 gene is associated with increased risk of coronary artery disease in Chinese Han population: A large angiography-based study. Atherosclerosis. 2010;210(1):160-5

15.Luan B, Han Y, Zhang X, Kang J, Yan C. Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population. Mol Biol Rep. 2010;37(1):399-403.

16.Han Y, Li N, Tian X, Kang J, Yan C, Qi Y. Endogenous transforming growth factor (TGF) beta1 promotes differentiation of smooth muscle cells from embryonic stem cells: stable plasmid-based siRNA silencing of TGF beta1 gene expression. J Physiol Sci. 2010;60(1):35-41.

17.Pei F, Han Y, Zhang X, Yan C, Huang M, Deng J, Kang J. Association analysis of the IL-17F His161Arg polymorphism in myocardial infarction. Coron Artery Dis. 2009;20(8):513-7.

18.Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Yan C. CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis. Exp Cell Res. 2009;315(19):3301-11.

19.Zhang X, Han Y, Kang J, Yan C. A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population. Clin Chim Acta. 2009;403(1-2):241-3

20.Pei F, Han Y, Zhang X, Yan C, Huang M, Huang L, Kang J. Association of interleukin-18 gene promoter polymorphisms with risk of acute myocardial infarction in northern Chinese Han population. Clin Chem Lab Med. 2009;47(5):523-9.

21.Han Y, Wu Z, Zhang X, Yan C, Xi S, Yang Y, Pei F, Kang J.Impact of matrix metalloproteinase-1 gene variations on risk of acute coronary syndrome. Coron Artery Dis. 2008;19(4):227-30.

22.Han Y, Guo L, Yan C, Guo P, Deng J, Mai X, Kang J, Li S. Adenovirus- mediated intra-arterial delivery of CREG attenuates neointima formation in rabbits after balloon injury. J Vasc Surg. 2008;48(1):201-9.

23.Han Y, Deng J, Guo L, Yan C, Liang M, Kang J, Liu H, Graham AM, Li S. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. Cardiovasc Res. 2008;78(3):597-604.

24.Han Y, Xi S, Zhang X, Yan C, Yang Y, Kang J. Association of connexin 37 gene polymorphisms with risk of coronary artery disease in northern Han Chinese. Cardiology 2008;110(4):260-5.

25.Han YL, Guo P, Sun MY, Guo L, Luan B, Kang J, Yan CH, Li SH. Secreted CREG inhibits cell proliferation mediated by mannose 6-phosphate/insulin-like growth factor II receptor in NIH3T3 fibroblasts. Genes Cells 2008; 13(9):977-86.

26.Han Y, Qi Y, Kang J, Li N, Tian X, Yan C. Nerve growth factor promotes formation of lumen-like structures in vitro through inducing apoptosis in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2008; 366(3):685-91.

PARTERNS:

National creative patents: The production and utilization of recombinant protein of the cellular repressor of E1A regulated genes

No：200810000053.8，Data: Mar 1, 2012.

AWARD:

1.‘Second Prize of Liaoning province Science & technology Development’ in 2011 (the secondary co-author)

2.‘Second Prize of National Science & technology Development’ in 2013(the sixth co-author)