Personal details
Address: The Wellcome Trust Sanger Institute
Wellcome Trust Genome Campus
Cambs. CB10 1SA
UK
E-mail: ylx@sanger.ac.uk
Date of birth: 07.03.1967
Education:
1985-1990: Dept. of Public Health, Harbin Medical University, China. B.M. degree
1990-1993: Dept. of Epidemiology, Harbin Medical University, China. M.Sc. degree
1998-2001: Dept. of Biology, Harbin Medical University, China. Ph.D. degree
Employment:
1993-1998: Teaching assistant and Research Assistant, Dept. of Biology, Harbin Medical University, China.
1998-2001: Lecturer, Dept. of Biology, Harbin Medical University, China.
2001-2003: Associate Professor, Dept. of Biology, Harbin Medical University, China.
2001-2002: Postdoctoral Fellow, Dept. of Chemistry, Cleveland University, USA.
2003-2004: Professor, Dept. of Biology, Harbin Medical University, China.
2004-2009: Staff Scientist, The Wellcome Trust Sanger Institute, Hinxton, UK.
2009-present: Senior Staff Scientist, The Wellcome Trust Sanger Institute, Hinxton, UK.
Research interests:
1. Human Y-chromosomal genetic diversity and human Y chromosome population genetics
2. Positive selection in recent human history
3. Human population genomics and human evolution
4. The functional genomics of human genetic variation
Research achievement highlights:
1. Human Y-chromosomal diversity: First suggestion that there are 16 million men carrying Genghis Khan’s Y chromosome and 1.5 million carrying Nurhachi’s in today’s population, showing that the two non-Han dynasties have left detectable genetic traces in modern populations. Another piece of work also showed that northern and southern populations in East Asia followed dramatically different fates around 30,000 years ago. Northern populations expanded in numbers much earlier, perhaps because they could hunt and eat mammoths and other large animals: an abundant source of nutrition.
2. Positive selection in the human genome: Identified the Caspase 12 gene as a good example of the ‘less is more’ hypothesis in humans, where the inactivation of the gene was positively selected about 50,000 years ago, perhaps due to the protection it provided from severe sepsis caused by bacterial and other infections. This work is now a module for the A-level biology courses in UK. Similar story for UGT2B17 copy number variation, as well as dozens of genes with highly differentiated nonsynonymous changes.
3. Involvement in the Genographic project: Revealed the legacies left by travellers to and invaders of Lebanon - showing that the Crusaders left chromosomes as well as castles. Lebanese Christian men are more likely to carry genetic signatures found in Europe, thought to have been carried there by the Crusades.
4. Human evolution and population genetics questions: Applying new sequencing technology to address human evolution and population genetics questions, e.g. first time directly measuring human Y mutation rate, an essential parameter for population and medical genetics.
5. Involvement in the 1000 Genomes Project: contributed to the project in the areas of Y-chromosomal diversity, a genome-wide scan for positive selection, identifying disease variants in the general population, and functional prediction of the consequences of variants. This large international project produced the first map of human genomic variation based on population-scale resequencing.
6. Involvement in the international Gorilla Genome Project: contributed to the project by analysing functional variants and disease variants, as well as evolutionary aspects. The project showed that hearing genes have evolved in gorillas at a similar rate to those in humans, and that some genetic variants that cause rare genetic disease in humans – dementia or heart failure, for example – are normal in gorillas and don’t cause disease in them. This is important for human medical genetic studies.
List of publications 2003-2014
Research articles:
1. Zerjal, T., Xue, Y., Bertorelle, G., Wells, R. S., Bao, W., Zhu, S., Qamar, R., Ayub, Q., Mohyuddin, A., Fu, S., Li, P., Yuldasheva, N., Ruzibakiev, R., Xu, J., Shu, Q., Du, R., Yang, H., Hurles, M. E., Robinson, E., Gerelsaikhan, T., Dashnyam, B., Mehdi, S. Q. and Tyler-Smith, C. (2003) The genetic legacy of the Mongols. Am. J. Hum. Genet. 72, 717-721.
2. Xue, Y., Zerjal, T., Bao, W., Zhu, S., Lim, S.-K., Shu, Q., Xu, J., Du, R., Fu, S., Li, P., Yang, H. and Tyler-Smith, C. (2005) Recent spread of a Y-chromosomal lineage in Northern China and Mongolia. Am. J. Hum. Genet.77, 1112-1116.
3. Xue, Y., Daly, A., Yngvadottir, B., Liu, M., Coop, G., Kim, Y., Sabeti, P., Chen, Y., Stalker, J., Huckle, E., Burton, J., Leonard, S., Rogers, J. and Tyler-Smith, C. (2006) Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am. J. Hum. Genet. 78, 659-670.
4. Xue, Y., Zerjal, T., Bao, W., Zhu, S., Lim, S.-K., Shu, Q., Xu, J., Du, R., Fu, S., Li, P., Hurles, M. E., Yang, H. and Tyler-Smith, C. (2006) Male demography in East Asia: a north-south contrast in human population expansion times. Genetics172, 2431-2439.
5. Jobling, M. A., Lo, I. C. C., Turner, D. J., Bowden, G. R., Lee, A. C., Xue, Y., Carvalho-Silva, D., Hurles, M. E., Adams, S. M., Chang, Y. M., Kraaijenbrink, T., Henke, J., Guanti, G., McKeown, B., van Oorschot, R. A. H., Mitchell, R. J., de Knijff, P., Tyler-Smith, C. and Parkin, E. J. (2007) Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y. Hum. Mol. Genet. 16, 307-316.
6. King, T. E., Parkin, E. J., Swinfield, G., Cruciani, F., Scozzari, R., Rosa, A, Lim, S.-K., Xue, Y., Tyler-Smith, C. and Jobling, M. A. (2007) Africans in Yorkshire? - the deepest-rooting clade of the Y phylogeny within an English genealogy. Eur. J. Hum. Genet. 15, 288-293
7. Lim, S.-K., Xue, Y., Parkin, E. and Tyler-Smith, C. (2007) Variation of 52 new Y-STR loci in the Y Chromosome Consortium worldwide panel of 76 diverse individuals. Int. J. Legal Med. 121, 124-127.
8. Powell, G. T., Yang, H., Tyler-Smith, C. and Xue, Y. (2007) The population history of the Xibe in northern China: a comparison of autosomal, mtDNA and Y-chromosomal analyses of migration and gene flow. FSI Genetics 1, 115-119.
9. Xu, Y., Xue, Y., Asan, Daly, A., Wu, L. and Tyler-Smith, C. (2008) Variation of the Oxytocin/Neurophysin I (OXT) gene in four human populations. J. Hum. Genet. 53, 637-643.
10. Xue, Y., Sun, D., Daly, A., Yang, F., Zhou, X., Zhao, M., Huang, N., Zerjal, T., Lee, C., Carter, N. P., Hurles, M. E. and Tyler-Smith, C. (2008) Adaptive evolution of UGT2B17 copy number variation. Am. J. Hum. Genet. 83, 337-346.
11. Zalloua, P. A., Platt, D. E., El Sibai, M., Khalife, J., Makhoul, N., Haber, M., Xue, Y., Izaabel, H., Bosch, E., Adams, S. M., Arroyo, E., López-Parra, A. M., Aler, M., Picornell, A., Ramon, M., Jobling, M. A., Comas, D., Bertranpetit, J., Wells, R. S., Tyler-Smith, C. and The Genographic Consortium. Identifying genetic traces of historical expansions: Phoenician footprints in the Mediterranean. Am. J. Hum. Genet. 83, 633-642.
12. Zalloua, P. A., Xue, Y., Khalife, J., Makhoul, N., Debiane, L., Platt, D. E., Royyuru, A. K., Herrera, R. J., Soria Hernanz, D. F., Blue-Smith, J., Wells, R. S., Comas, D., Bertranpetit, J., Tyler-Smith, C. and The Genographic Consortium (2008) Y-chromosomal diversity in Lebanon is structured by recent historical events. Am. J. Hum. Genet. 82, 873-882.
13. Dhandapany, P. S., Sadayappan, S., Xue, Y., Powell, G. T., Rani, D. S., Nallari, P., Rai, T. S., Khullar, M., Soares, P., Bahl, A., Tharkan, J. M., Vaideeswar, P., Rathinavel, A., Narasimhan, C., Ayapati, D. R., Ayub, Q., Mehdi, S. Q., Oppenheimer, S., Richards, M., Price, A., Patterson, N., Reich, D., Singh, L., Tyler-Smith, C. and Thangaraj, K. (2009) A common MYBPC3(cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nature Genet. 41, 187-191.
14. El-Sibai, M., Platt, D. E., Haber, M., Xue, Y., Youhanna, S. C., Wells, R. S., Izaabel, H., Sanyoura, M. F., Harmanani, H., Ashrafian-Bonab, M., Behbehani, J., Hashwa, F., Tyler-Smith, C., Zalloua, P. A. and The Genographic Consortium. Geographical structure of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast. (2009) Ann. Hum. Genet. 73, 568-581.
15. Giachini, C., Nuti, F., Turner, D. J., Laface, I., Xue, Y., Daguin, F., Forti, G., Tyler-Smith, C. and Krausz, C. (2009) TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages. J. Clin. Endocrinol. Metab. 94, 4016-4122.
16. He, M., Gitschier, J., Zerjal, T., de Knijff, P., Tyler-Smith, C. and Xue, Y. (2009) Geographical affinities of the HapMap samples. PLoS ONE, e4684.
17. Krausz, C., Giachini, C., Xue, Y., O'Bryan, M. K., Gromoll, J. , Rajpert-de Meyts, E., Oliva, R., Aknin-Seifer, I., Erdei, E., Jorgensen, N., Simoni, M., Ballescà, J. L., Levy, R., Balercia, G., Piomboni, P., Nieschlag, E., Forti, G., McLachlan, R. and Tyler-Smith, C. (2009) Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background. J. Med. Genet. 46, 21-31.
18. Mohammad, T., Xue, Y., Evison, M. and Tyler-Smith, C. (2009) Genetic structure of nomadic Bedouin from Kuwait. Heredity 103, 425-433.
19. Soranzo, N., Spector, T. D., Mangino, M, Kühnel, B., Rendon , A., Teumer, A., Willenborg, C., Wright, B., Chen, L., Li, M., Salo, P., Voight, B. F., Burns, P., Laskowski, R. A., Xue, Y., Menze, S., Altshuler, D., Bradley, J. R., Bumpstead, S., Burnett, M.-S., Devaney, J., Döring, A., Elosua, R., Epstein, S., Erber, W., Falchi, M., Garner, S. F., Ghori, M. J. R., Goodall, A. H., Gwilliam, R., Hall, A. S., Hammond, N., Hengstenberg, C., Illig, T., König, I. R., Knouff, C. W., McPherson, R., Melander, O., Mooser, V., Nauck, M., Nieminen, M. S., O'Donnell, C. J., Peltonen, L., Potter, S. C., Prokisch, H., Rader, D. J., Rice, C. M., Roberts, R., Salomaa, V., Sambrook, J., Schreiber, S., Schunkert , H., Schwartz, S. M., Serbanovic-Canic, J., Sinisalo, J., Siscovick, D. S., Stark, K., Stephens, J., Thompson, J. R., Völker, U., Völzke, H., Watkins, N. A., Wells, G. A., Wichmann, H.-E., Van Heel, D., Tyler-Smith, C., Thein, S. L., Kathiresan, S., Perola, M., Reilly, M. P., Stewart, A. F. R., Erdmann, J., Samani, N. J., Meisinger, C., Greinacher, A., Deloukas, P., Ouwehand, W. H. and Gieger, C. (2009) A meta-analysis of eight hematological parameters identifies 22 associated loci and extensive disease pleiotropy on chromosome 12q24. Nature Genet. 41,1182-1190.
20. Tarpey, P. S., Smith, R., Pleasance, E., Whibley, A., Edkins, S., Hardy, C., O’Meara, S., Latimer, C., Dicks, E., Menzies, A., Stephens, P., Blow, M., Greenman, C., Xue, Y., Tyler-Smith, C., Thompson, D., Gray, K., Andrews, J., Barthorpe, S., Buck, G., Cole, J., Dunmore, R., Jones, D., Maddison, M., Mironenko, T., Turner, R., Turrell, K., Varian, J., West, S., Widaa, S., Wray, P., Teague, J., Butler, A., Jenkinson, A., Jia, M., Richardson, D., Shepherd, R., Wooster, R., Tejada, M. I., Martinez, F., Carvill, G., Goliath, R., de Brouwer, A. P. M., van Bokhoven, H., Van Esch, H., Chelly, J., Raynaud, M., Ropers, H.-H., Abidi, F. E., Srivastava, A. K., Cox, J., Luo, Y., Mallya, U., Moon, J., Parnau, J., Mohammed, S., Tolmie, J. L., Shoubridge, C., Corbett, M., Gardner, A., Haan, E., Rujirabanjerd, S., Shaw, M., Vandeleur, L., Fullston, T., Easton, D. F., Boyle, J., Partington, M., Hackett, A., Field, M., Skinner, C., Stevenson, R. E., Bobrow, M., Turner, G., Schwartz, C. E., Gecz, J., Raymond, F. L., Futreal, P. A., and Stratton, M. R. (2009) A systematic, large-scale resequencing screen of the X chromosome coding exons in mental retardation. Nature Genet. 41, 535-543.
21. Vermeulen, M., Wollstein, A., van der Gaag, K., Lao, O., Xue, Y., Wang, Q., Roewer, L., Knoblauch, H., Tyler-Smith, C., de Knijff, P. and Kayser, M. (2009) Improving global and regional resolution of male lineage differentiation by simple single-copy Y-chromosomal short tandem repeat polymorphisms. FSI Genet. 3, 205-213.
22. Xue, Y., Wang, Q., Long, Q., Ng, B. L., Swerdlow, H., Burton, J., Skuce, C., Taylor, R., Abdellah, Z. Zhao, Y., Asan, MacArthur, D. G., Quail, M. A., Carter, N. P., Yang, H. and Tyler-Smith, C. (2009) Human Y chromosome base substitution mutation rate measured by direct sequencing in a deep-rooting pedigree. Curr. Biol. 19, 1453-1457.
23. Xue, Y., Zhang, X., Huang, N., Daly, A., Gillson, C. J., MacArthur, D. G., Yngvadottir, B., Nica, A. C., Woodwark, C., Chen, Y., Conrad, D. F., Ayub, Q., Mehdi, S. Q., Li, P. and Tyler-Smith, C. (2009) Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation. Genetics183, 1065-1077.
24. Yngvadottir, B., Xue, Y., Searle, S., Hunt, S., Delgado, M., Morrison, J., Whittaker, P., Deloukas, P. and Tyler-Smith, C. (2009) A genomewide survey of the prevalence and evolutionary forces acting on human nonsense-SNPs. Am. J. Hum. Genet. 84, 224-234.
25. Shi, W., Ayub, Q., Vermeulem, M., Shao, R., Zuniga, S., van der Gaag, K., de Knijff, P., Kayser, M., Xue, Y. and Tyler-Smith, C. (2010) A worldwide survey of human male demographic history based on Y-SNP and Y-STR data from the HGDP-CEPH populations. Mol. Biol. Evol. 27, 385-393.
26. The 1000 Genomes Project Consortium (2010) A map of human genome variation from population scale sequencing. Nature 467, 1061-1073.
27. Asan, Xu, Y., Jiang, H., Tyler-Smith, C., Goodman, L., Xue, Y., Jiang, T., Wang, J., Wu, M., Tian, G., Wang, J., Wang, J., Yang, H. and Zhang, X. (2011) Comprehensive comparison of three commercial human whole-exome capture platforms. Genome Biol. 12, R95
28. Chaubey, G., Metspalu, M., Choi, Y., Mägi, R., Gallego Romero, I., Soares, P., van Oven, M., Behar, D. M., Rootsi, S., Hudjashov, G., Mallick, C. B., Karmin, M., Nelis, M., Parik, J., Reddy, A. G., Metspalu, E., van Driem, G., Xue, Y., Tyler-Smith, C., Thangaraj, K., Singh, L., Remm, M., Richards, M. B., Lahr, M. M., Kayser, M., Villems, R. and Kivisild, T. (2011) Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture. Mol. Biol. Evol. 28, 1013-1024.
29. de Gruijter, J. M., Lao, O., Vermeulen, M., Xue, Y., Woodwark, C., Gillson, C. J., Coffey, A. J., Ayub, Q., Mehdi, S. Q., Kayser, M. and Tyler-Smith, C. (2012) Contrasting signals of positive selection in genes involved in human skin color variation from tests based on SNP scans and resequencing. Invest. Genet. 2, 24
30. Haber, M., Platt, D. E., Badro, D. A., Xue, Y., El-Sibai, M., Bonab, M. A., Youhanna, S. C., Saade, S., Soria-Hernanz, D. F., Royyuru, A., Wells, R. S., Tyler-Smith, C., Zalloua, P. A. and The Genographic Consortium (2011) Influences of history, geography and religion on genetic structure: the Maronites in Lebanon. Eur. J. Hum. Genet. 19, 334-340.
31. Hardwick, R. J., Machado, L. R., Zuccherato, L. W., Antolinos, S., Xue, Y., Shawa, N., Gilman, R. H., Cabrera, L., Berg, D. E., Tyler-Smith, C., Kelly, P., Tarazona-Santos, E. and Hollox, E. J. (2011) A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia. Hum. Mut. 32, 743-550.
32. Marth, G. T., Yu, F., Indap, A. R., Garimella, K., Gravel, S., Leong, W. F., Tyler-Smith, C., Bainbridge, M., Blackwell, T., Zheng-Bradley, X., Chen, Y., Challis, D., Clarke, L., Ball, E. V., Cibulskis, K., Cooper, D. N., Fulton, B., Hartl, C., Koboldt, D., Muzny, D., Smith, R., Sougnez, C., Stewart, C., Ward, A., Yu, J., Xue, Y., Altshuler, D., Bustamante, C. D., Clark, A. C., Daly, M., DePristo, M., Flicek, P., Gabriel, S., Mardis, E., Palotie, A., Gibbs, R. and The 1000 Genomes Project (2011) The functional spectrum of low-frequency coding variation. Genome Biol. 12, R84
33. Zhou, X., Xu, Y., Wang, J., Zhou, H., Liu, X., Ayub, Q., Wang, X., Tyler-Smith, C., Wu, L. and Xue, Y. (2011) Replication of the association of a MET variant with autism in a Chinese Han population. PLoS ONE 6, e27428.
34. Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R, Feeley, E. M., Sims, J. S., Adams, D. J., Wise, H. M., Kane, L., Goulding, D. A., Digard, P., Anttila, V., J. Baillie, K., Walsh, T. S., Hume, D. A., Palotie, A., Xue, Y., Colonna, V., Tyler-Smith, C., Dunning, J., Gordon, D., The GenISIS Investigators, The MOSAIC Investigators, Smyth, S., Openshaw, P., Dougan, G., Brass, A. L., & Kellam, P. (2012) IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 484, 519-523.
35. Hu, M., Ayub, Q., Guerra-Assunção, J., Long, Q., Ning, Z., Huang, N., Gallago Romero, I., Mamanova, L., Akan, P., Liu, X., Coffey, A. J., Turner, D. J., Swerdlow, H., Burton, J., Quail, M. A., Conrad, D. F., Enright, A. J., Tyler-Smith, C. and Xue, Y. (2012) Exploration of signals of positive selection derived from genotype-based human genome scans using re-sequencing data. Hum. Genet. 131, 665-674.
36. MacArthur, D. G., Balasubramanian, S., Frankish, A., Huang, N., Morris, J., Walter, K., Jostins, L., Habegger, L., Pickrell, J. K., Montgomery, S. B., Albers, C. A., Zhang, Z., Conrad, D. F., Lunter, G., Zheng, H., Ayub, Q., DePristo, M. A., Banks, E., Hu, M., Handsaker, R. E., Rosenfeld, J., Fromer, M., Jin, M., Mu, X. J., Khurana, E., Ye, K., Kay, M., Saunders, G. I., Suner, M., Hunt, T., Barnes, I., Amid, C., Carvalho-Silva, D. R., Bignell, A. H., Snow, C., Yngvadottir, B., Bumpstead, S., Cooper, D. N., Xue, Y., Romero, I. G., 1000 Genomes Project Consortium, Wang, J., Li, Y., Gibbs, R. A., McCarroll, S. A., Dermitzakis, E. T., Pritchard, J. K., Barrett, J. C., Harrow, J., Hurles, M. E., Gerstein, M. B., Tyler-Smith1, C. (2012) A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes. Science 335, 823–828.
37. Pagani, L., Ayub, Q., MacArthur, D. G., Xue, Y., Baillie, J. K., Chen, Y., Kozarewa, I., Turner, D. J., Tofanelli, S., Bulayeva, K., Kidd, K., Paoli, G. and Tyler-Smith, C. (2012) High altitude adaptation in Daghestani populations from the Caucasus. Hum. Genet. 131, 423-433.
38. Perry, G. H., Xue, Y., Smith, R. S., Meyer, W. K., Caliskan, M., Yanez-Cuna, O., Lee, A. S., Gutierrez-Arcelus, M., Ober, C., Hollox, E. J., Tyler-Smith, C. and Lee, C. (2012) Evolutionary genetics of the human Rh blood group system. Hum Genet. (in press)
39. Scally, A., Dutheil, J.G., Hillier L. W., Jordan, G. E., Goodhead, I., Herrero, J., Hobolth, A., Lappalainen, T., Mailund, T., Marques-Bonet, T., McCarthy, S., Montgomery, S. H., Schwalie, P. C., Tang, Y. A., Ward, M. C., Xue, Y., Yngvadottir, B., Alkan, C., Andersen, L. N., Ayub, Q., Ball, E. V., Beal, K., Bradley, B. J., Chen, Y., Clee, C. M., Fitzgerald, S., Graves, T. A., Gu, Y., Heath, P., Heger, A., Karakoc, E., Kolb-Kokocinski, A., Laird, G. K., Lunter, G., Meader, S., Mort, M., Mullikin, J. C., Munch, K., O’Connor, D. O., Phillips, A. D., Prado-Martinez, J., Rogers A. S., Sajjadian, S., Schmidt, D., Shaw, K., Simpson J. T., Stenson, P. D., Turner, D. J., Vigilant, L., Vilella, A. J., Whitener, W., Zhu1, B., Cooper, D. N., Jong, P., Dermitzakis, E. T., Eichler, E. E., Flicek, P., Goldman, N., Mundy, N. I., Ning, Z., Odom, D. T., Ponting, C. P., Quail, M. A., Ryder, O. A., Searle, S. M., Warren W. C., Wilson, R. K., Schierup, M. H., Rogers, J., Tyler-Smith, C., & Durbin R,. (2012) Insights into hominid evolution from the gorilla genome sequence. Nature.483, 169-175.
Ayub Q, Xue Y and Tyler-Smith C. (2013) Genomic triumph meets clinical reality. Genome biology. 14;5;
41. Ayub Q, Yngvadottir B, Chen Y, Xue Y, Hu M, Vernes SC, Fisher SE and Tyler-Smith C. (2013) FOXP2 targets show evidence of positive selection in European populations. American journal of human genetics 92;5;696-706
42. Elhaik E, Greenspan E, Staats S, Krahn T, Tyler-Smith C, Xue Y, Tofanelli S, Francalacci P, Cucca F, Pagani L, Jin L, Li H, Schurr TG,Greenspan B, Spencer Wells R and Genographic Consortium. (2013) The GenoChip: a new tool for genetic anthropology. Genome biology and evolution 5;5;1021-31
43. Khurana E, Fu Y, Colonna V, Mu XJ, Kang HM, Lappalainen T, Sboner A, Lochovsky L, Chen J, Harmanci A, Das J, Abyzov A,Balasubramanian S, Beal K, Chakravarty D, Challis D, Chen Y, Clarke D, Clarke L, Cunningham F, Evani US, Flicek P, Fragoza R, Garrison E,Gibbs R, Gümüs ZH, Herrero J, Kitabayashi N, Kong Y, Lage K, Liluashvili V, Lipkin SM, MacArthur DG, Marth G, Muzny D, Pers TH, Ritchie GR, Rosenfeld JA, Sisu C, Wei X, Wilson M, Xue Y, Yu F, 1000 Genomes Project Consortium, Dermitzakis ET, Yu H, Rubin MA, Tyler-Smith Cand Gerstein M (2013) Integrative annotation of variants from 1092 humans: application to cancer genomics. Science 342;6154;1235587
44. Scally A, Yngvadottir B, Xue Y, Ayub Q, Durbin R and Tyler-Smith C (2013)A genome-wide survey of genetic variation in gorillas using reduced representation sequencing. PloS one 8;6;e65066
45. Sikora MJ, Colonna V, Xue Y and Tyler-Smith C (2013) Modeling the contrasting Neolithic male lineage expansions in Europe and Africa. Investigative genetics 4;1;25
46. Tachmazidou I, Dedoussis G, Southam L, Farmaki AE, Ritchie GR, Xifara DK, Matchan A, Hatzikotoulas K, Rayner NW, Chen Y, Pollin TI,O'Connell JR, Yerges-Armstrong LM, Kiagiadaki C, Panoutsopoulou K, Schwartzentruber J, Moutsianas L, UK10K consortium, Tsafantakis E,Tyler-Smith C, McVean G, Xue Y and Zeggini E (2013) A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates. Nature communications 4;2872
47. Wang Q, Xue Y, Zhang Y, Long Q, Asan, Yang F, Turner DJ, Fitzgerald T, Ng BL, Zhao Y, Chen Y, Liu Q, Yang W, Han D, Quail MA, Swerdlow H, Burton J, Fahey C, Ning Z, Hurles ME, Carter NP, Yang H and Tyler-Smith C (2013) Genetic basis of Y-linked hearing impairment. American journal of human genetics 92;2;301-6
48. Wei W, Ayub Q, Chen Y, McCarthy S, Hou Y, Carbone I, Xue Y and Tyler-Smith C (2013) A calibrated human Y-chromosomal phylogeny based on resequencing. Genome research 23;2;388-95
49. Wei W, Ayub Q, Xue Y and Tyler-Smith C (2013) A comparison of Y-chromosomal lineage dating using either resequencing or Y-SNP plus Y-STR genotyping. Forensic science international. Genetics 2013;7;6;568-72
50. Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V, Pagani L, Prokopenko I, Ritchie GR, Tyler-Smith C, McCarthy MI, Zeggini E and Xue Y (2014) Revisiting the Thrifty Gene Hypothesis via 65 Loci Associated with Susceptibility to Type 2 Diabetes. American journal of human genetics
Review articles:
51. Xue, Y. and Tyler-Smith, C. (2010a) The hare and the tortoise: one small step for four SNPs, one giant leap for SNP-kind. FSI Genet. 4, 59-61.
52. Xue, Y. and Tyler-Smith, C. (2010b) Response to the comment on "The hare and the tortoise: one small step for four SNPs, one giant leap for SNP-kind". [Discussion] FSI Genet. 5, 361-362
53. Colona, V., Pagani, L., Xue, Y. and Tyler-Smith, C. (2011) A world in a grain of sand: human history from genetic data. Genome Biol. 12, 234.
54. Tyler-Smith, C. and Xue, Y. (2011) A British approach to sampling. [Editorial] Eur. J. Hum. Genet. 20, 129-130.
55. Xue, Y. and Tyler-Smith, C. (2011) An exceptional gene: evolution of the TSPYgene family in humans and other great apes. Genes 2, 36-47.
56. Xue, Y. and Tyler-Smith, C. (2012) The 1000 Genomes Project: discovering human DNA variation. [School science education] Biol. Sci. Rev. 24, 34-38
57. Tyler-Smith, C. and Xue, Y. (2012) Sibling Rivalry among Paralogs Promotes Evolution of the Human Brain. Cell. 149, 737-739.
Book Chapters
58. Xue, Y., Bao, W., Zhu, S., Su, Q., Xu, J., Du, R., Yang, H., Fu, S., Li, P., Zerjal, T. and Tyler-Smith, C. (2006) Y-chromosomal DNA variation in East Asia.In:Il DNA Nella Società Attuale: Test Genetici, Diastri di Massa, Identificazione Criminale. Atti del XX Congresso Nazionale dei Genetisti Italiana, Bologna, 9-11 Settembre 2004. Cicognana, A. and Pelotti, S. (eds.) Giuffrè Editore, Milan, Italy, pp. 125-139.
59. Xue, Y. and Tyler-Smith, C. (2008) Segmental Duplications and their role in the evolution of the human genome. In Encyclopedia of Life Sciences. John Wiley and Sons, Ltd., Chichester. DOI: 10.1002/9780470015902.a0020838.
60. Xue, Y., Zerjal, T., Bao, W., Zhu, S., Lim, S.-K., Shu, Q., Xu, J., Du, R., Fu, S., Li, P., Hurles, M. E., Yang, H. and Tyler-Smith, C. (2008) Modelling male prehistory in East Asia using BATWING. In: Simulations, Genetics and Prehistory: a Focus on Islands. Matsumura, S., Forster, P. and Renfrew, C. (eds.), McDonald Institute, Cambridge, UK, pp. 81-90.
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