Welcome to the website for the Laboratory of Medical Genetics at Harbin Medical University. Our lab was established by eminent Professor Li Pu in 1950. In the early years, we contributed greatly in the cytogenetic study of solid tumors. Until now, our lab has been a multidisciplinary research platform for professionals dedicated to developing molecular biological, biochemical, cytogenetic and human genetic strategies to dissect the molecular and genetic mechanisms of oncogenesis.
We currently have a strong interest in double minute chromosomes (DMs), which is a special type of oncogenetic information carrier, working as an extrachromosomal gene amplification and usually carrying oncogenes and drug resistance genes. To elucidate the role of DMs in oncogenesis, we explore a range of biochemical and cytogenetic techniques to investigate the precise ultrastructure features of DMs, the origination and specificity of DMs in different tumors, genes carried by DMs and their related signaling transduction pathways, as well as the progression of DMs in drug resistant human solid tumors.
We also focus on understanding the molecular mechanisms of the growth, differentiation and metastasis of solid tumor, including the signaling pathways that positively and negatively regulate activation of tumor related genes, as well as identifying and evaluating potential target genes for therapeutic intervention. Finally, as one of the three major national centers participating in the Chinese Human Genome Project (CHGP), we are committed to preserving the genetic resource of Chinese minority populations with the goal of exploring their genetic diversity and investigating the association of genetic variants in human diseases.